The m(6)A‑methylase complex and mRNA export()

During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs...

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Autores principales: Lesbirel, Simon, Wilson, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414750/
https://www.ncbi.nlm.nih.gov/pubmed/30290229
http://dx.doi.org/10.1016/j.bbagrm.2018.09.008
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author Lesbirel, Simon
Wilson, Stuart A.
author_facet Lesbirel, Simon
Wilson, Stuart A.
author_sort Lesbirel, Simon
collection PubMed
description During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N(6)‑methyladenosine (m(6)A) modification. In this review we discuss the recent evidence of coupling between the m(6)A modification, RNA processing and export.
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spelling pubmed-64147502019-03-25 The m(6)A‑methylase complex and mRNA export() Lesbirel, Simon Wilson, Stuart A. Biochim Biophys Acta Gene Regul Mech Article During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N(6)‑methyladenosine (m(6)A) modification. In this review we discuss the recent evidence of coupling between the m(6)A modification, RNA processing and export. Elsevier 2019-03 /pmc/articles/PMC6414750/ /pubmed/30290229 http://dx.doi.org/10.1016/j.bbagrm.2018.09.008 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Lesbirel, Simon
Wilson, Stuart A.
The m(6)A‑methylase complex and mRNA export()
title The m(6)A‑methylase complex and mRNA export()
title_full The m(6)A‑methylase complex and mRNA export()
title_fullStr The m(6)A‑methylase complex and mRNA export()
title_full_unstemmed The m(6)A‑methylase complex and mRNA export()
title_short The m(6)A‑methylase complex and mRNA export()
title_sort m(6)a‑methylase complex and mrna export()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414750/
https://www.ncbi.nlm.nih.gov/pubmed/30290229
http://dx.doi.org/10.1016/j.bbagrm.2018.09.008
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