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The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis

Novel agents are urgently needed to rapidly kill drug-resistant Mycobacterium tuberculosis. Noble metal complexes, particularly polypyridyl iridium complexes serving as therapeutic agents, have attracted considerable interest recently, due to their significant cytotoxic or antimicrobial activities....

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Detalles Bibliográficos
Autores principales: Liao, Guojian, Peng, Xixi, Li, Ting, Ye, Zhengyuan, Xiang, Xiaohong, Fu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414957/
https://www.ncbi.nlm.nih.gov/pubmed/30966332
http://dx.doi.org/10.3390/polym10030297
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author Liao, Guojian
Peng, Xixi
Li, Ting
Ye, Zhengyuan
Xiang, Xiaohong
Fu, Chen
author_facet Liao, Guojian
Peng, Xixi
Li, Ting
Ye, Zhengyuan
Xiang, Xiaohong
Fu, Chen
author_sort Liao, Guojian
collection PubMed
description Novel agents are urgently needed to rapidly kill drug-resistant Mycobacterium tuberculosis. Noble metal complexes, particularly polypyridyl iridium complexes serving as therapeutic agents, have attracted considerable interest recently, due to their significant cytotoxic or antimicrobial activities. Here, we reported an polypyridyl iridium dimer complex [Ir(ppy)(2)Cl](2) (3), with ppy = phenylpyridine, which was found to be active against both exponential growing and non-replicating M. smegmatis, with minimum inhibitory concentration values of 2 μg/mL, and exhibited rapid bactericidal kinetics, killing pathogens within 30–60 min. Moreover, 3 was demonstrated to generate a large amount of reactive oxygen species and to be effective in drug-resistant strains. Taken together, the selectively active iridium(III) dimer complex showed promise for use as a novel drug candidate for the treatment of M. tuberculosis infection.
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spelling pubmed-64149572019-04-02 The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis Liao, Guojian Peng, Xixi Li, Ting Ye, Zhengyuan Xiang, Xiaohong Fu, Chen Polymers (Basel) Article Novel agents are urgently needed to rapidly kill drug-resistant Mycobacterium tuberculosis. Noble metal complexes, particularly polypyridyl iridium complexes serving as therapeutic agents, have attracted considerable interest recently, due to their significant cytotoxic or antimicrobial activities. Here, we reported an polypyridyl iridium dimer complex [Ir(ppy)(2)Cl](2) (3), with ppy = phenylpyridine, which was found to be active against both exponential growing and non-replicating M. smegmatis, with minimum inhibitory concentration values of 2 μg/mL, and exhibited rapid bactericidal kinetics, killing pathogens within 30–60 min. Moreover, 3 was demonstrated to generate a large amount of reactive oxygen species and to be effective in drug-resistant strains. Taken together, the selectively active iridium(III) dimer complex showed promise for use as a novel drug candidate for the treatment of M. tuberculosis infection. MDPI 2018-03-09 /pmc/articles/PMC6414957/ /pubmed/30966332 http://dx.doi.org/10.3390/polym10030297 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liao, Guojian
Peng, Xixi
Li, Ting
Ye, Zhengyuan
Xiang, Xiaohong
Fu, Chen
The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis
title The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis
title_full The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis
title_fullStr The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis
title_full_unstemmed The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis
title_short The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis
title_sort discovery of an iridium(iii) dimer complex as a potent antibacterial agent against non-replicating mycobacterium smegmatis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414957/
https://www.ncbi.nlm.nih.gov/pubmed/30966332
http://dx.doi.org/10.3390/polym10030297
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