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The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections

The most frequent diseases of the urinary bladder are bacterial infections and bladder cancers. For both diseases, very high recurrence rates are characteristic: 50–80% for bladder cancer and more than 50% for bladder infections, causing loss of millions of dollars per year for medical treatment and...

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Detalles Bibliográficos
Autores principales: Erman, Andreja, Veranič, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414971/
https://www.ncbi.nlm.nih.gov/pubmed/30966300
http://dx.doi.org/10.3390/polym10030265
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author Erman, Andreja
Veranič, Peter
author_facet Erman, Andreja
Veranič, Peter
author_sort Erman, Andreja
collection PubMed
description The most frequent diseases of the urinary bladder are bacterial infections and bladder cancers. For both diseases, very high recurrence rates are characteristic: 50–80% for bladder cancer and more than 50% for bladder infections, causing loss of millions of dollars per year for medical treatment and sick leave. Despite years of searching for better treatment, the prevalence of bladder infections and bladder cancer remains unchanged and is even increasing in recent years. Very encouraging results in treatment of both diseases recently culminated from studies combining biopolymer chitosan with immunotherapy, and chitosan with antibiotics for treatment of bladder cancer and cystitis, respectably. In both pathways of research, the discoveries involving chitosan reached a successful long-lasting cure. The property of chitosan that boosted the effectivity of illness-specific drugs is its ability to enhance the accessibility of these drugs to the very sources of both pathologies that individual treatments without chitosan failed to achieve. Chitosan can thus be recognised as a very promising co-player in treatment of bladder cancer and bacterial cystitis.
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spelling pubmed-64149712019-04-02 The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections Erman, Andreja Veranič, Peter Polymers (Basel) Review The most frequent diseases of the urinary bladder are bacterial infections and bladder cancers. For both diseases, very high recurrence rates are characteristic: 50–80% for bladder cancer and more than 50% for bladder infections, causing loss of millions of dollars per year for medical treatment and sick leave. Despite years of searching for better treatment, the prevalence of bladder infections and bladder cancer remains unchanged and is even increasing in recent years. Very encouraging results in treatment of both diseases recently culminated from studies combining biopolymer chitosan with immunotherapy, and chitosan with antibiotics for treatment of bladder cancer and cystitis, respectably. In both pathways of research, the discoveries involving chitosan reached a successful long-lasting cure. The property of chitosan that boosted the effectivity of illness-specific drugs is its ability to enhance the accessibility of these drugs to the very sources of both pathologies that individual treatments without chitosan failed to achieve. Chitosan can thus be recognised as a very promising co-player in treatment of bladder cancer and bacterial cystitis. MDPI 2018-03-05 /pmc/articles/PMC6414971/ /pubmed/30966300 http://dx.doi.org/10.3390/polym10030265 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Erman, Andreja
Veranič, Peter
The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections
title The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections
title_full The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections
title_fullStr The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections
title_full_unstemmed The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections
title_short The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections
title_sort use of polymer chitosan in intravesical treatment of urinary bladder cancer and infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414971/
https://www.ncbi.nlm.nih.gov/pubmed/30966300
http://dx.doi.org/10.3390/polym10030265
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