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Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion

The aim of this study was to investigate the effect of acrylate modification on the mucoadhesion of chitosan at the nanoscale. Nanoparticles were fabricated from acrylated chitosan (ACS) via ionic gelation with tripolyphosphate and were characterized in terms of size, zeta potential, stability, and...

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Detalles Bibliográficos
Autores principales: Eliyahu, Shaked, Aharon, Anat, Bianco-Peled, Havazelet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415080/
https://www.ncbi.nlm.nih.gov/pubmed/30966139
http://dx.doi.org/10.3390/polym10020106
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author Eliyahu, Shaked
Aharon, Anat
Bianco-Peled, Havazelet
author_facet Eliyahu, Shaked
Aharon, Anat
Bianco-Peled, Havazelet
author_sort Eliyahu, Shaked
collection PubMed
description The aim of this study was to investigate the effect of acrylate modification on the mucoadhesion of chitosan at the nanoscale. Nanoparticles were fabricated from acrylated chitosan (ACS) via ionic gelation with tripolyphosphate and were characterized in terms of size, zeta potential, stability, and nanoparticle yield. Chitosan (CS) nanoparticles, serving as a control, were fabricated using the same procedure. The mucoadhesion of the nanoparticles was evaluated using the flow-through method after different incubation periods. The retention percentages of ACS nanoparticles were found to be significantly higher than those of CS nanoparticles, for all studied time intervals. An additional indication for the increased mucoadhesion of ACS nanoparticles was the increase in particle size obtained from the mucin particle method, in which mucin and nanoparticles are mixed at different ratios. NMR data verified the presence of free acrylate groups on the ACS nanoparticles. Thus, the improved mucoadhesion could be due to a Michael-type addition reaction between the nanoparticles and thiol groups present in mucin glycoprotein, in addition to entanglements and hydrogen bonding. Overall, ACS nanoparticles exhibit enhanced mucoadhesion properties as compared to CS nanoparticles and could be used as vehicles for drug delivery systems.
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spelling pubmed-64150802019-04-02 Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion Eliyahu, Shaked Aharon, Anat Bianco-Peled, Havazelet Polymers (Basel) Article The aim of this study was to investigate the effect of acrylate modification on the mucoadhesion of chitosan at the nanoscale. Nanoparticles were fabricated from acrylated chitosan (ACS) via ionic gelation with tripolyphosphate and were characterized in terms of size, zeta potential, stability, and nanoparticle yield. Chitosan (CS) nanoparticles, serving as a control, were fabricated using the same procedure. The mucoadhesion of the nanoparticles was evaluated using the flow-through method after different incubation periods. The retention percentages of ACS nanoparticles were found to be significantly higher than those of CS nanoparticles, for all studied time intervals. An additional indication for the increased mucoadhesion of ACS nanoparticles was the increase in particle size obtained from the mucin particle method, in which mucin and nanoparticles are mixed at different ratios. NMR data verified the presence of free acrylate groups on the ACS nanoparticles. Thus, the improved mucoadhesion could be due to a Michael-type addition reaction between the nanoparticles and thiol groups present in mucin glycoprotein, in addition to entanglements and hydrogen bonding. Overall, ACS nanoparticles exhibit enhanced mucoadhesion properties as compared to CS nanoparticles and could be used as vehicles for drug delivery systems. MDPI 2018-01-23 /pmc/articles/PMC6415080/ /pubmed/30966139 http://dx.doi.org/10.3390/polym10020106 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Eliyahu, Shaked
Aharon, Anat
Bianco-Peled, Havazelet
Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion
title Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion
title_full Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion
title_fullStr Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion
title_full_unstemmed Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion
title_short Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion
title_sort acrylated chitosan nanoparticles with enhanced mucoadhesion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415080/
https://www.ncbi.nlm.nih.gov/pubmed/30966139
http://dx.doi.org/10.3390/polym10020106
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