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Investigation on the Nanomechanics of Liposome Adsorption on Titanium Alloys: Temperature and Loading Effects

The mechanical properties of liposomes, determined by the lipid phase state at ambient temperature, have a close relationship with their physiological activities. Here, atomic force microscopy (AFM) was used to produce images and perform force measurements on titanium alloys at two adsorbed temperat...

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Detalles Bibliográficos
Autores principales: Duan, Yiqin, Liu, Yuhong, Li, Jinjin, Wang, Hongdong, Wen, Shizhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415199/
https://www.ncbi.nlm.nih.gov/pubmed/30966418
http://dx.doi.org/10.3390/polym10040383
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author Duan, Yiqin
Liu, Yuhong
Li, Jinjin
Wang, Hongdong
Wen, Shizhu
author_facet Duan, Yiqin
Liu, Yuhong
Li, Jinjin
Wang, Hongdong
Wen, Shizhu
author_sort Duan, Yiqin
collection PubMed
description The mechanical properties of liposomes, determined by the lipid phase state at ambient temperature, have a close relationship with their physiological activities. Here, atomic force microscopy (AFM) was used to produce images and perform force measurements on titanium alloys at two adsorbed temperatures. The mechanical properties were evaluated under repeated loading and unloading, suggesting a better reversibility and resistance of gel phase liposomes. The liquid phase liposomes were irreversibly damaged during the first approach while the gel phase liposomes could bear more iterations, resulting from water flow reversibly going across the membranes. The statistical data offered strong evidence that the lipid membranes in the gel phase are robust enough to resist the tip penetration, mainly due to their orderly organization and strong hydrophobic interactions between lipid molecules. This work regarding the mechanical properties of liposomes with different phases provides guidance for future clinical applications, such as artificial joints.
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spelling pubmed-64151992019-04-02 Investigation on the Nanomechanics of Liposome Adsorption on Titanium Alloys: Temperature and Loading Effects Duan, Yiqin Liu, Yuhong Li, Jinjin Wang, Hongdong Wen, Shizhu Polymers (Basel) Article The mechanical properties of liposomes, determined by the lipid phase state at ambient temperature, have a close relationship with their physiological activities. Here, atomic force microscopy (AFM) was used to produce images and perform force measurements on titanium alloys at two adsorbed temperatures. The mechanical properties were evaluated under repeated loading and unloading, suggesting a better reversibility and resistance of gel phase liposomes. The liquid phase liposomes were irreversibly damaged during the first approach while the gel phase liposomes could bear more iterations, resulting from water flow reversibly going across the membranes. The statistical data offered strong evidence that the lipid membranes in the gel phase are robust enough to resist the tip penetration, mainly due to their orderly organization and strong hydrophobic interactions between lipid molecules. This work regarding the mechanical properties of liposomes with different phases provides guidance for future clinical applications, such as artificial joints. MDPI 2018-04-01 /pmc/articles/PMC6415199/ /pubmed/30966418 http://dx.doi.org/10.3390/polym10040383 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Duan, Yiqin
Liu, Yuhong
Li, Jinjin
Wang, Hongdong
Wen, Shizhu
Investigation on the Nanomechanics of Liposome Adsorption on Titanium Alloys: Temperature and Loading Effects
title Investigation on the Nanomechanics of Liposome Adsorption on Titanium Alloys: Temperature and Loading Effects
title_full Investigation on the Nanomechanics of Liposome Adsorption on Titanium Alloys: Temperature and Loading Effects
title_fullStr Investigation on the Nanomechanics of Liposome Adsorption on Titanium Alloys: Temperature and Loading Effects
title_full_unstemmed Investigation on the Nanomechanics of Liposome Adsorption on Titanium Alloys: Temperature and Loading Effects
title_short Investigation on the Nanomechanics of Liposome Adsorption on Titanium Alloys: Temperature and Loading Effects
title_sort investigation on the nanomechanics of liposome adsorption on titanium alloys: temperature and loading effects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415199/
https://www.ncbi.nlm.nih.gov/pubmed/30966418
http://dx.doi.org/10.3390/polym10040383
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