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HEVnet: a One Health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis E virus molecular typing, characterisation and epidemiological investigations

Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Despite an increased incidence of hepatiti...

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Autores principales: Mulder, Annemieke Christine, Kroneman, Annelies, Franz, Eelco, Vennema, Harry, Tulen, Anna D., Takkinen, Johanna, Hofhuis, Agnetha, Adlhoch, Cornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415499/
https://www.ncbi.nlm.nih.gov/pubmed/30862334
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.10.1800407
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author Mulder, Annemieke Christine
Kroneman, Annelies
Franz, Eelco
Vennema, Harry
Tulen, Anna D.
Takkinen, Johanna
Hofhuis, Agnetha
Adlhoch, Cornelia
author_facet Mulder, Annemieke Christine
Kroneman, Annelies
Franz, Eelco
Vennema, Harry
Tulen, Anna D.
Takkinen, Johanna
Hofhuis, Agnetha
Adlhoch, Cornelia
author_sort Mulder, Annemieke Christine
collection PubMed
description Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Despite an increased incidence of hepatitis E across Europe, much remains unknown about its spread, sources and transmission routes. A One Health approach is crucial to better understand the (molecular) epidemiology of HEV. HEVnet was established in April 2017 as a network and database for sharing sequences and accompanying metadata collected from human, animal, food and environmental sources. HEVnet members working in the public health, veterinary health, food, environmental and blood safety sectors have submitted 1,615 HEV sequences from nine countries as at January 2019. Most are from humans (89%), and sequences of animal (5%), food (6%) or environmental (0.3%) origin are rare. Metadata for human sequences capture mostly sex (93%), year of birth (92%) and sampling (100%); data on region of sampling (37%) and clinical information (hospitalisation 27%, symptoms 20% or mortality 8%) are limited. HEVnet aims to expand into a global network capable of performing cross-sectoral and supranational studies, with a joint repository of molecular and epidemiological data on HEV.
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spelling pubmed-64154992019-04-11 HEVnet: a One Health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis E virus molecular typing, characterisation and epidemiological investigations Mulder, Annemieke Christine Kroneman, Annelies Franz, Eelco Vennema, Harry Tulen, Anna D. Takkinen, Johanna Hofhuis, Agnetha Adlhoch, Cornelia Euro Surveill Perspective Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Despite an increased incidence of hepatitis E across Europe, much remains unknown about its spread, sources and transmission routes. A One Health approach is crucial to better understand the (molecular) epidemiology of HEV. HEVnet was established in April 2017 as a network and database for sharing sequences and accompanying metadata collected from human, animal, food and environmental sources. HEVnet members working in the public health, veterinary health, food, environmental and blood safety sectors have submitted 1,615 HEV sequences from nine countries as at January 2019. Most are from humans (89%), and sequences of animal (5%), food (6%) or environmental (0.3%) origin are rare. Metadata for human sequences capture mostly sex (93%), year of birth (92%) and sampling (100%); data on region of sampling (37%) and clinical information (hospitalisation 27%, symptoms 20% or mortality 8%) are limited. HEVnet aims to expand into a global network capable of performing cross-sectoral and supranational studies, with a joint repository of molecular and epidemiological data on HEV. European Centre for Disease Prevention and Control (ECDC) 2019-03-07 /pmc/articles/PMC6415499/ /pubmed/30862334 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.10.1800407 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Perspective
Mulder, Annemieke Christine
Kroneman, Annelies
Franz, Eelco
Vennema, Harry
Tulen, Anna D.
Takkinen, Johanna
Hofhuis, Agnetha
Adlhoch, Cornelia
HEVnet: a One Health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis E virus molecular typing, characterisation and epidemiological investigations
title HEVnet: a One Health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis E virus molecular typing, characterisation and epidemiological investigations
title_full HEVnet: a One Health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis E virus molecular typing, characterisation and epidemiological investigations
title_fullStr HEVnet: a One Health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis E virus molecular typing, characterisation and epidemiological investigations
title_full_unstemmed HEVnet: a One Health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis E virus molecular typing, characterisation and epidemiological investigations
title_short HEVnet: a One Health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis E virus molecular typing, characterisation and epidemiological investigations
title_sort hevnet: a one health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis e virus molecular typing, characterisation and epidemiological investigations
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415499/
https://www.ncbi.nlm.nih.gov/pubmed/30862334
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.10.1800407
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