The entropic force generated by intrinsically disordered segments tunes protein function

Protein structures are dynamic and can explore a large conformational landscape(1,2). Only some of these structural substates are important for protein function (i.e. ligand binding, catalysis and regulation)(3–5). How evolution shapes the structural ensemble to optimize a specific function is poorl...

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Detalles Bibliográficos
Autores principales: Keul, Nicholas D., Oruganty, Krishnadev, Bergman, Elizabeth T. Schaper, Beattie, Nathaniel R., McDonald, Weston E., Kadirvelraj, Renuka, Gross, Michael L., Phillips, Robert S., Harvey, Stephen C., Wood, Zachary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415545/
https://www.ncbi.nlm.nih.gov/pubmed/30420606
http://dx.doi.org/10.1038/s41586-018-0699-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415545/
https://www.ncbi.nlm.nih.gov/pubmed/30420606
http://dx.doi.org/10.1038/s41586-018-0699-5

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