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The entropic force generated by intrinsically disordered segments tunes protein function
Protein structures are dynamic and can explore a large conformational landscape(1,2). Only some of these structural substates are important for protein function (i.e. ligand binding, catalysis and regulation)(3–5). How evolution shapes the structural ensemble to optimize a specific function is poorl...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415545/ https://www.ncbi.nlm.nih.gov/pubmed/30420606 http://dx.doi.org/10.1038/s41586-018-0699-5 |