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Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents
Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Genética
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415595/ https://www.ncbi.nlm.nih.gov/pubmed/30507998 http://dx.doi.org/10.1590/1678-4685-GMB-2017-0195 |
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author | Gasparin, Caroline C. Leite, Neiva Tureck, Luciane V. Souza, Ricardo L.R. Milano-Gai, Gerusa E. Silva, Larissa R. Lopes, Wendell A. Furtado-Alle, Lupe |
author_facet | Gasparin, Caroline C. Leite, Neiva Tureck, Luciane V. Souza, Ricardo L.R. Milano-Gai, Gerusa E. Silva, Larissa R. Lopes, Wendell A. Furtado-Alle, Lupe |
author_sort | Gasparin, Caroline C. |
collection | PubMed |
description | Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0.015 and p=0.012, respectively), while the ε3 allele was associated with higher abdominal circumference (p=0.0416) and excess weight (p=0.0001). The G allele (rs846910) of the HSD11β1 gene was also associated with excess weight (p=0.039). No other association was found. Our results indicate that the ε4 and ε2 alleles could contribute to lower HDL-C and LDL-C levels, respectively, furthermore, the ε3 allele and the G allele (rs846910) of HSD11β1 gene may be risk factors for excess of weight.These findings are very important because we observed that some genetic variants influence the lipid profile and anthropometric variables early in life. |
format | Online Article Text |
id | pubmed-6415595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-64155952019-03-21 Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents Gasparin, Caroline C. Leite, Neiva Tureck, Luciane V. Souza, Ricardo L.R. Milano-Gai, Gerusa E. Silva, Larissa R. Lopes, Wendell A. Furtado-Alle, Lupe Genet Mol Biol Human and Medical Genetics Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0.015 and p=0.012, respectively), while the ε3 allele was associated with higher abdominal circumference (p=0.0416) and excess weight (p=0.0001). The G allele (rs846910) of the HSD11β1 gene was also associated with excess weight (p=0.039). No other association was found. Our results indicate that the ε4 and ε2 alleles could contribute to lower HDL-C and LDL-C levels, respectively, furthermore, the ε3 allele and the G allele (rs846910) of HSD11β1 gene may be risk factors for excess of weight.These findings are very important because we observed that some genetic variants influence the lipid profile and anthropometric variables early in life. Sociedade Brasileira de Genética 2018-11-23 2018 /pmc/articles/PMC6415595/ /pubmed/30507998 http://dx.doi.org/10.1590/1678-4685-GMB-2017-0195 Text en Copyright © 2018, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited. |
spellingShingle | Human and Medical Genetics Gasparin, Caroline C. Leite, Neiva Tureck, Luciane V. Souza, Ricardo L.R. Milano-Gai, Gerusa E. Silva, Larissa R. Lopes, Wendell A. Furtado-Alle, Lupe Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents |
title | Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents |
title_full | Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents |
title_fullStr | Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents |
title_full_unstemmed | Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents |
title_short | Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents |
title_sort | effects of polymorphisms in apob, apoe, hsd11β1, plin4, and adipoq genes on lipid profile and anthropometric variables related to obesity in children and adolescents |
topic | Human and Medical Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415595/ https://www.ncbi.nlm.nih.gov/pubmed/30507998 http://dx.doi.org/10.1590/1678-4685-GMB-2017-0195 |
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