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The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females

Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to bio...

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Autores principales: Roll, Mariana Matos, Miranda-Vilela, Ana Luisa, Longo, João Paulo Figueiró, Agostini-Costa, Tania da Silveira, Grisolia, Cesar Koppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415600/
https://www.ncbi.nlm.nih.gov/pubmed/30507999
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0218
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author Roll, Mariana Matos
Miranda-Vilela, Ana Luisa
Longo, João Paulo Figueiró
Agostini-Costa, Tania da Silveira
Grisolia, Cesar Koppe
author_facet Roll, Mariana Matos
Miranda-Vilela, Ana Luisa
Longo, João Paulo Figueiró
Agostini-Costa, Tania da Silveira
Grisolia, Cesar Koppe
author_sort Roll, Mariana Matos
collection PubMed
description Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to biomolecules and inflammation. We aimed to investigate in vivo the antioxidant and anti-inflammatory effects of pequi oil on hemogram and DNA damage in healthy young adult and older middle-aged Swiss mice of both genders. Animals, aged 6-7 and 11-12 months, were orally treated for 15 days with pequi oil at 30 mg/day. Blood samples were used for hemogram and comet assay, and bone marrow for micronucleus test. Female controls of 11-12 months had significantly lower haemoglobin and hematocrit than those of 6-7 months. Treatment with pequi oil improved this state, removing the differences. Pequi oil had no genotoxic or clastogenic effects and significantly increased lymphocytes and decreased neutrophils+monocytes in females of 11-12 months, removing the significant differences observed between controls of 6-7 and 11-12 months. The results suggest that dietary supplementation with pequi oil could protect against anemia, inflammation and oxidative stress related to aging, helping to prevent aging-related chronic degenerative diseases, mainly for females.
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spelling pubmed-64156002019-03-21 The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females Roll, Mariana Matos Miranda-Vilela, Ana Luisa Longo, João Paulo Figueiró Agostini-Costa, Tania da Silveira Grisolia, Cesar Koppe Genet Mol Biol Mutagenesis Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to biomolecules and inflammation. We aimed to investigate in vivo the antioxidant and anti-inflammatory effects of pequi oil on hemogram and DNA damage in healthy young adult and older middle-aged Swiss mice of both genders. Animals, aged 6-7 and 11-12 months, were orally treated for 15 days with pequi oil at 30 mg/day. Blood samples were used for hemogram and comet assay, and bone marrow for micronucleus test. Female controls of 11-12 months had significantly lower haemoglobin and hematocrit than those of 6-7 months. Treatment with pequi oil improved this state, removing the differences. Pequi oil had no genotoxic or clastogenic effects and significantly increased lymphocytes and decreased neutrophils+monocytes in females of 11-12 months, removing the significant differences observed between controls of 6-7 and 11-12 months. The results suggest that dietary supplementation with pequi oil could protect against anemia, inflammation and oxidative stress related to aging, helping to prevent aging-related chronic degenerative diseases, mainly for females. Sociedade Brasileira de Genética 2018-11-29 2018 /pmc/articles/PMC6415600/ /pubmed/30507999 http://dx.doi.org/10.1590/1678-4685-GMB-2017-0218 Text en Copyright © 2018, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Mutagenesis
Roll, Mariana Matos
Miranda-Vilela, Ana Luisa
Longo, João Paulo Figueiró
Agostini-Costa, Tania da Silveira
Grisolia, Cesar Koppe
The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_full The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_fullStr The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_full_unstemmed The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_short The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_sort pequi pulp oil (caryocar brasiliense camb.) provides protection against aging-related anemia, inflammation and oxidative stress in swiss mice, especially in females
topic Mutagenesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415600/
https://www.ncbi.nlm.nih.gov/pubmed/30507999
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0218
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