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Testing the Cre-mediated genetic switch for the generation of conditional knock-in mice

The Cre-mediated genetic switch combines the ability of Cre recombinase to stably invert or excise a DNA fragment depending upon the orientation of flanking mutant loxP sites. In this work, we have tested this strategy in vivo with the aim to generate two conditional knock-in mice for missense mutat...

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Detalles Bibliográficos
Autores principales:	Capulli, Mattia, Costantini, Rossella, Sonntag, Stephan, Maurizi, Antonio, Paganini, Chiara, Monti, Luca, Forlino, Antonella, Shmerling, Doron, Teti, Anna, Rossi, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415906/ https://www.ncbi.nlm.nih.gov/pubmed/30865697 http://dx.doi.org/10.1371/journal.pone.0213660

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