The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer

Recent studies of the patterns of chemokine-mediated immune cell recruitment into solid tumors have enhanced our understanding of the role played by various immune cell subsets both in amplifying and inhibiting tumor cell growth and spread. Here we discuss how the chemokine/chemokine receptor networ...

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Detalles Bibliográficos
Autores principales: Yam, Andrew O., Chtanova, Tatyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416210/
https://www.ncbi.nlm.nih.gov/pubmed/30899263
http://dx.doi.org/10.3389/fimmu.2019.00386
Descripción
Sumario:Recent studies of the patterns of chemokine-mediated immune cell recruitment into solid tumors have enhanced our understanding of the role played by various immune cell subsets both in amplifying and inhibiting tumor cell growth and spread. Here we discuss how the chemokine/chemokine receptor networks bring together immune cells within the microenvironment of skin tumors, particularly melanomas, including their effect on disease progression, prognosis and therapeutic options.

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