The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer

Recent studies of the patterns of chemokine-mediated immune cell recruitment into solid tumors have enhanced our understanding of the role played by various immune cell subsets both in amplifying and inhibiting tumor cell growth and spread. Here we discuss how the chemokine/chemokine receptor networ...

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Detalles Bibliográficos
Autores principales: Yam, Andrew O., Chtanova, Tatyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416210/
https://www.ncbi.nlm.nih.gov/pubmed/30899263
http://dx.doi.org/10.3389/fimmu.2019.00386
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author Yam, Andrew O.
Chtanova, Tatyana
author_facet Yam, Andrew O.
Chtanova, Tatyana
author_sort Yam, Andrew O.
collection PubMed
description Recent studies of the patterns of chemokine-mediated immune cell recruitment into solid tumors have enhanced our understanding of the role played by various immune cell subsets both in amplifying and inhibiting tumor cell growth and spread. Here we discuss how the chemokine/chemokine receptor networks bring together immune cells within the microenvironment of skin tumors, particularly melanomas, including their effect on disease progression, prognosis and therapeutic options.
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spelling pubmed-64162102019-03-21 The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer Yam, Andrew O. Chtanova, Tatyana Front Immunol Immunology Recent studies of the patterns of chemokine-mediated immune cell recruitment into solid tumors have enhanced our understanding of the role played by various immune cell subsets both in amplifying and inhibiting tumor cell growth and spread. Here we discuss how the chemokine/chemokine receptor networks bring together immune cells within the microenvironment of skin tumors, particularly melanomas, including their effect on disease progression, prognosis and therapeutic options. Frontiers Media S.A. 2019-03-07 /pmc/articles/PMC6416210/ /pubmed/30899263 http://dx.doi.org/10.3389/fimmu.2019.00386 Text en Copyright © 2019 Yam and Chtanova. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yam, Andrew O.
Chtanova, Tatyana
The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer
title The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer
title_full The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer
title_fullStr The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer
title_full_unstemmed The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer
title_short The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer
title_sort ins and outs of chemokine-mediated immune cell trafficking in skin cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416210/
https://www.ncbi.nlm.nih.gov/pubmed/30899263
http://dx.doi.org/10.3389/fimmu.2019.00386
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