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Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues

Hepatic encephalopathy (HE) has a major impact on health-related quality of life (HRQOL) in patients, which has clinical and psychosocial consequences. HRQOL in cirrhosis has been measured by generic and liver-specific instruments, with most studies indicating a negative impact of HE. HRQOL abnormal...

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Detalles Bibliográficos
Autores principales: Montagnese, Sara, Bajaj, Jasmohan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416233/
https://www.ncbi.nlm.nih.gov/pubmed/30706419
http://dx.doi.org/10.1007/s40265-018-1019-y
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author Montagnese, Sara
Bajaj, Jasmohan S.
author_facet Montagnese, Sara
Bajaj, Jasmohan S.
author_sort Montagnese, Sara
collection PubMed
description Hepatic encephalopathy (HE) has a major impact on health-related quality of life (HRQOL) in patients, which has clinical and psychosocial consequences. HRQOL in cirrhosis has been measured by generic and liver-specific instruments, with most studies indicating a negative impact of HE. HRQOL abnormalities span daily functioning, sleep–wake cycle changes, and the ability to work. Of these, sleep–wake cycle changes have a major effect on HRQOL, which remains challenging to treat. The personal effect of HRQOL is modulated by the presence of HE, the etiology of cirrhosis, and cognitive reserve. Patients with higher cognitive reserve are able to tolerate HE and its impact on HRQOL better than those with a poor cognitive reserve. The impact of HRQOL impairment is felt by patients (higher mortality and poor daily functioning), as well as by caregivers and families. Caregivers of patients with HE bear a major financial and psychological burden, which may affect their personal health and longevity.
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spelling pubmed-64162332019-04-03 Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues Montagnese, Sara Bajaj, Jasmohan S. Drugs Review Article Hepatic encephalopathy (HE) has a major impact on health-related quality of life (HRQOL) in patients, which has clinical and psychosocial consequences. HRQOL in cirrhosis has been measured by generic and liver-specific instruments, with most studies indicating a negative impact of HE. HRQOL abnormalities span daily functioning, sleep–wake cycle changes, and the ability to work. Of these, sleep–wake cycle changes have a major effect on HRQOL, which remains challenging to treat. The personal effect of HRQOL is modulated by the presence of HE, the etiology of cirrhosis, and cognitive reserve. Patients with higher cognitive reserve are able to tolerate HE and its impact on HRQOL better than those with a poor cognitive reserve. The impact of HRQOL impairment is felt by patients (higher mortality and poor daily functioning), as well as by caregivers and families. Caregivers of patients with HE bear a major financial and psychological burden, which may affect their personal health and longevity. Springer International Publishing 2019-01-31 2019 /pmc/articles/PMC6416233/ /pubmed/30706419 http://dx.doi.org/10.1007/s40265-018-1019-y Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Montagnese, Sara
Bajaj, Jasmohan S.
Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues
title Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues
title_full Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues
title_fullStr Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues
title_full_unstemmed Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues
title_short Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues
title_sort impact of hepatic encephalopathy in cirrhosis on quality-of-life issues
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416233/
https://www.ncbi.nlm.nih.gov/pubmed/30706419
http://dx.doi.org/10.1007/s40265-018-1019-y
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