The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism

In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (A...

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Detalles Bibliográficos
Autores principales: Misselbeck, Karla, Marchetti, Luca, Priami, Corrado, Stover, Patrick J., Field, Martha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416297/
https://www.ncbi.nlm.nih.gov/pubmed/30867454
http://dx.doi.org/10.1038/s41598-019-40230-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416297/
https://www.ncbi.nlm.nih.gov/pubmed/30867454
http://dx.doi.org/10.1038/s41598-019-40230-4

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