Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

Vascular calcification is highly prevalent in end-stage renal diseases and is predictive of cardiovascular events and mortality. Poly(ADP-ribose) polymerase 1 (PARP1) inhibition or deletion is vasoprotective in several disease models. Here we show that PARP activity is increased in radial artery sam...

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Detalles Bibliográficos
Autores principales: Wang, Cheng, Xu, Wenjing, An, Jie, Liang, Minglu, Li, Yiqing, Zhang, Fengxiao, Tong, Qiangsong, Huang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416341/
https://www.ncbi.nlm.nih.gov/pubmed/30867423
http://dx.doi.org/10.1038/s41467-019-09174-1

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