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The contraceptive medroxyprogesterone acetate, unlike norethisterone, directly increases R5 HIV-1 infection in human cervical explant tissue at physiologically relevant concentrations

The intramuscular progestin-only injectable contraceptive, depo-medroxyprogesterone acetate (DMPA-IM), is more widely used in Sub-Saharan Africa than another injectable contraceptive, norethisterone enanthate (NET-EN). Epidemiological data show a significant 1.4-fold increased risk of HIV-1 acquisit...

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Detalles Bibliográficos
Autores principales:	Ray, Roslyn M., Maritz, Michelle F., Avenant, Chanel, Tomasicchio, Michele, Dlamini, Sigcinile, van der Spuy, Zephne, Hapgood, Janet P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416361/ https://www.ncbi.nlm.nih.gov/pubmed/30867477 http://dx.doi.org/10.1038/s41598-019-40756-7

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