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Anemia Screening, Prevalence, and Treatment in Pediatric Inflammatory Bowel Disease in the United States, 2010–2014

PURPOSE: We examined the prevalence of anemia, annual screening for anemia, and treatment of anemia with iron among children with inflammatory bowel disease (IBD). METHODS: A retrospective study of U.S. pediatric patients with IBD was performed in the MarketScan commercial claims database from 2010–...

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Autores principales: Miller, Steven D., Cuffari, Carmelo, Akhuemonkhan, Eboselume, Guerrerio, Anthony L., Lehmann, Harold, Hutfless, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416389/
https://www.ncbi.nlm.nih.gov/pubmed/30899691
http://dx.doi.org/10.5223/pghn.2019.22.2.152
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author Miller, Steven D.
Cuffari, Carmelo
Akhuemonkhan, Eboselume
Guerrerio, Anthony L.
Lehmann, Harold
Hutfless, Susan
author_facet Miller, Steven D.
Cuffari, Carmelo
Akhuemonkhan, Eboselume
Guerrerio, Anthony L.
Lehmann, Harold
Hutfless, Susan
author_sort Miller, Steven D.
collection PubMed
description PURPOSE: We examined the prevalence of anemia, annual screening for anemia, and treatment of anemia with iron among children with inflammatory bowel disease (IBD). METHODS: A retrospective study of U.S. pediatric patients with IBD was performed in the MarketScan commercial claims database from 2010–2014. Children (ages 1–21) with at least two inpatient or outpatient encounters for IBD who had available lab and pharmacy data were included in the cohort. Anemia was defined using World Health Organization criteria. We used logistic regression to determine differences in screening, incident anemia, and treatment based on age at first IBD encounter and sex. RESULTS: The cohort (n=2,446) included 1,560 Crohn's disease (CD) and 886 ulcerative colitis (UC). Approximately, 85% of CD and 81% of UC were screened for anemia. Among those screened, 51% with CD and 43% with UC had anemia. Only 24% of anemia patients with CD and 20% with UC were tested for iron deficiency; 85% were iron deficient. Intravenous (IV) iron was used to treat 4% of CD and 4% UC patients overall and 8% of those with anemia. CONCLUSION: At least 80% of children with IBD were screened for anemia, although most did not receive follow-up tests for iron deficiency. The 43%–50% prevalence of anemia was consistent with prior studies. Under-treatment with IV iron points to a potential target for quality improvement.
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spelling pubmed-64163892019-03-21 Anemia Screening, Prevalence, and Treatment in Pediatric Inflammatory Bowel Disease in the United States, 2010–2014 Miller, Steven D. Cuffari, Carmelo Akhuemonkhan, Eboselume Guerrerio, Anthony L. Lehmann, Harold Hutfless, Susan Pediatr Gastroenterol Hepatol Nutr Original Article PURPOSE: We examined the prevalence of anemia, annual screening for anemia, and treatment of anemia with iron among children with inflammatory bowel disease (IBD). METHODS: A retrospective study of U.S. pediatric patients with IBD was performed in the MarketScan commercial claims database from 2010–2014. Children (ages 1–21) with at least two inpatient or outpatient encounters for IBD who had available lab and pharmacy data were included in the cohort. Anemia was defined using World Health Organization criteria. We used logistic regression to determine differences in screening, incident anemia, and treatment based on age at first IBD encounter and sex. RESULTS: The cohort (n=2,446) included 1,560 Crohn's disease (CD) and 886 ulcerative colitis (UC). Approximately, 85% of CD and 81% of UC were screened for anemia. Among those screened, 51% with CD and 43% with UC had anemia. Only 24% of anemia patients with CD and 20% with UC were tested for iron deficiency; 85% were iron deficient. Intravenous (IV) iron was used to treat 4% of CD and 4% UC patients overall and 8% of those with anemia. CONCLUSION: At least 80% of children with IBD were screened for anemia, although most did not receive follow-up tests for iron deficiency. The 43%–50% prevalence of anemia was consistent with prior studies. Under-treatment with IV iron points to a potential target for quality improvement. The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition 2019-03 2019-02-27 /pmc/articles/PMC6416389/ /pubmed/30899691 http://dx.doi.org/10.5223/pghn.2019.22.2.152 Text en Copyright © 2019 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition https://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Miller, Steven D.
Cuffari, Carmelo
Akhuemonkhan, Eboselume
Guerrerio, Anthony L.
Lehmann, Harold
Hutfless, Susan
Anemia Screening, Prevalence, and Treatment in Pediatric Inflammatory Bowel Disease in the United States, 2010–2014
title Anemia Screening, Prevalence, and Treatment in Pediatric Inflammatory Bowel Disease in the United States, 2010–2014
title_full Anemia Screening, Prevalence, and Treatment in Pediatric Inflammatory Bowel Disease in the United States, 2010–2014
title_fullStr Anemia Screening, Prevalence, and Treatment in Pediatric Inflammatory Bowel Disease in the United States, 2010–2014
title_full_unstemmed Anemia Screening, Prevalence, and Treatment in Pediatric Inflammatory Bowel Disease in the United States, 2010–2014
title_short Anemia Screening, Prevalence, and Treatment in Pediatric Inflammatory Bowel Disease in the United States, 2010–2014
title_sort anemia screening, prevalence, and treatment in pediatric inflammatory bowel disease in the united states, 2010–2014
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416389/
https://www.ncbi.nlm.nih.gov/pubmed/30899691
http://dx.doi.org/10.5223/pghn.2019.22.2.152
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