Photoacoustic Wavefront Shaping with High Signal to Noise Ratio for Light Focusing Through Scattering Media

Noninvasive light focusing and imaging through a scattering medium can be achieved by wavefront shaping using the photoacoustic signal as feedback. Unfortunately, the signal to noise ratio (SNR) of the traditional photoacoustic method is very low, which limits the wavefront shaping focusing speed and intensity. In this paper, we propose a completely new photoacoustic-signal-extraction method which combines wavelet denoising and correlation detection. With this method, the SNR of the photoacoustic signal reaches 25.2, 6.5 times higher than that of the unprocessed photoacoustic signal. Moreover, we achieve the simultaneous multipoint focusing, which is crucial for improving the speed of scanning imaging. The superior performance of the proposed method was experimentally demonstrated in extracting and denoising the photoacoustic signals deeply buried in noise, one critical step in in vivo photoacoustic imaging.