Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice

Here we have characterized the functional impairments resulting from conditional knockout of the ubiquitin-conjugating E2 enzyme (UBC13) in rodent cerebellar granule neurons, which greatly increases the parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell synapses. We repor...

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Detalles Bibliográficos
Autores principales: Wozniak, David F., Valnegri, Pamela, Dearborn, Joshua T., Fowler, Stephen C., Bonni, Azad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416404/
https://www.ncbi.nlm.nih.gov/pubmed/30867488
http://dx.doi.org/10.1038/s41598-019-40714-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416404/
https://www.ncbi.nlm.nih.gov/pubmed/30867488
http://dx.doi.org/10.1038/s41598-019-40714-3

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