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Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives
With the unprecedented rise of drug-resistant pathogens, particularly antibiotic-resistant bacteria, and no new antibiotics in the pipeline over the last three decades, the issue of antimicrobial resistance has emerged as a critical public health threat. Antimicrobial Peptides (AMP) have garnered in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416458/ https://www.ncbi.nlm.nih.gov/pubmed/30370841 http://dx.doi.org/10.2174/0929866525666181026160852 |
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author | Sinha, Rajeshwari Shukla, Pratyoosh |
author_facet | Sinha, Rajeshwari Shukla, Pratyoosh |
author_sort | Sinha, Rajeshwari |
collection | PubMed |
description | With the unprecedented rise of drug-resistant pathogens, particularly antibiotic-resistant bacteria, and no new antibiotics in the pipeline over the last three decades, the issue of antimicrobial resistance has emerged as a critical public health threat. Antimicrobial Peptides (AMP) have garnered interest as a viable solution to this grave issue and are being explored for their potential antimicrobial applications. Given their low bioavailability in nature, tailoring new AMPs or strategizing approaches for increasing the yield of AMPs, therefore, becomes pertinent. The present review focuses on biotechnological interventions directed towards enhanced AMP syn-thesis and revisits existing genetic engineering and synthetic biology strategies for production of AMPs. This review further underscores the importance and potential applications of advanced gene editing technologies for the synthesis of novel AMPs in future. |
format | Online Article Text |
id | pubmed-6416458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-64164582019-04-10 Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives Sinha, Rajeshwari Shukla, Pratyoosh Protein Pept Lett Article With the unprecedented rise of drug-resistant pathogens, particularly antibiotic-resistant bacteria, and no new antibiotics in the pipeline over the last three decades, the issue of antimicrobial resistance has emerged as a critical public health threat. Antimicrobial Peptides (AMP) have garnered interest as a viable solution to this grave issue and are being explored for their potential antimicrobial applications. Given their low bioavailability in nature, tailoring new AMPs or strategizing approaches for increasing the yield of AMPs, therefore, becomes pertinent. The present review focuses on biotechnological interventions directed towards enhanced AMP syn-thesis and revisits existing genetic engineering and synthetic biology strategies for production of AMPs. This review further underscores the importance and potential applications of advanced gene editing technologies for the synthesis of novel AMPs in future. Bentham Science Publishers 2019-02 2019-02 /pmc/articles/PMC6416458/ /pubmed/30370841 http://dx.doi.org/10.2174/0929866525666181026160852 Text en © 2019 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Sinha, Rajeshwari Shukla, Pratyoosh Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives |
title | Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives |
title_full | Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives |
title_fullStr | Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives |
title_full_unstemmed | Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives |
title_short | Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives |
title_sort | antimicrobial peptides: recent insights on biotechnological interventions and future perspectives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416458/ https://www.ncbi.nlm.nih.gov/pubmed/30370841 http://dx.doi.org/10.2174/0929866525666181026160852 |
work_keys_str_mv | AT sinharajeshwari antimicrobialpeptidesrecentinsightsonbiotechnologicalinterventionsandfutureperspectives AT shuklapratyoosh antimicrobialpeptidesrecentinsightsonbiotechnologicalinterventionsandfutureperspectives |