Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice

We compare previously reported benzoporphyrin derivative (BPD)-mediated photodynamic therapy (PDT) results for reactive singlet oxygen concentration (also called singlet oxygen dose) on mice with simulations using a computational device, Dosie™, that calculates light transport and photokinetics for...

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Detalles Bibliográficos
Autores principales: Beeson, Karl W., Parilov, Evgueni, Potasek, Mary, Kim, Michele M., Zhu, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2019
Materias:
General
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416474/
https://www.ncbi.nlm.nih.gov/pubmed/30873764
http://dx.doi.org/10.1117/1.JBO.24.3.035006
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author Beeson, Karl W.
Parilov, Evgueni
Potasek, Mary
Kim, Michele M.
Zhu, Timothy C.
author_facet Beeson, Karl W.
Parilov, Evgueni
Potasek, Mary
Kim, Michele M.
Zhu, Timothy C.
author_sort Beeson, Karl W.
collection PubMed
description We compare previously reported benzoporphyrin derivative (BPD)-mediated photodynamic therapy (PDT) results for reactive singlet oxygen concentration (also called singlet oxygen dose) on mice with simulations using a computational device, Dosie™, that calculates light transport and photokinetics for PDT in near real-time. The two sets of results are consistent and validate the use of the device in PDT treatment planning to predict BPD-mediated PDT outcomes in mice animal studies based on singlet oxygen dose, which showed a much better correlation with the cure index than the conventional light dose.
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spelling pubmed-64164742020-01-22 Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice Beeson, Karl W. Parilov, Evgueni Potasek, Mary Kim, Michele M. Zhu, Timothy C. J Biomed Opt General We compare previously reported benzoporphyrin derivative (BPD)-mediated photodynamic therapy (PDT) results for reactive singlet oxygen concentration (also called singlet oxygen dose) on mice with simulations using a computational device, Dosie™, that calculates light transport and photokinetics for PDT in near real-time. The two sets of results are consistent and validate the use of the device in PDT treatment planning to predict BPD-mediated PDT outcomes in mice animal studies based on singlet oxygen dose, which showed a much better correlation with the cure index than the conventional light dose. Society of Photo-Optical Instrumentation Engineers 2019-03-14 2019-03 /pmc/articles/PMC6416474/ /pubmed/30873764 http://dx.doi.org/10.1117/1.JBO.24.3.035006 Text en © The Authors. https://creativecommons.org/licenses/by/3.0/ Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle General
Beeson, Karl W.
Parilov, Evgueni
Potasek, Mary
Kim, Michele M.
Zhu, Timothy C.
Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice
title Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice
title_full Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice
title_fullStr Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice
title_full_unstemmed Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice
title_short Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice
title_sort validation of combined monte carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice
topic General
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416474/
https://www.ncbi.nlm.nih.gov/pubmed/30873764
http://dx.doi.org/10.1117/1.JBO.24.3.035006
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