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Pseudoexfoliation Syndrome and Antidepressant Drug Use

OBJECTIVES: To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications. MATERIALS AND METHODS: This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institu...

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Autores principales: Yaşar, Erdoğan, Yıldırım, Nilgün, Atalay, Eray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416484/
https://www.ncbi.nlm.nih.gov/pubmed/30829017
http://dx.doi.org/10.4274/tjo.galenos.2018.06887
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author Yaşar, Erdoğan
Yıldırım, Nilgün
Atalay, Eray
author_facet Yaşar, Erdoğan
Yıldırım, Nilgün
Atalay, Eray
author_sort Yaşar, Erdoğan
collection PubMed
description OBJECTIVES: To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications. MATERIALS AND METHODS: This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institute database (www.turksat.gov.tr/) as part of an epidemiologic study which specifically aimed to detect the prevalence of PES in the province of Eskişehir. During the examination, a detailed questionnaire was administered to determine physician-diagnosed systemic disease and drug use. RESULTS: Eight of the 2,017 participants in the study were excluded for various reasons (2 with posterior synechiae, 2 with corneal opacity, 1 uncooperative patient, 1 eviscerated patient, 1 with active adenoviral keratoconjunctivitis, and 1 with a history of angle closure). PES was detected in 100 (5%) of the 2,009 patients whose data were analyzed. The percentage of subjects with concurrent antidepressant drug use in the PES and non-PES non-glaucoma groups were 4.1% (n=3) and 1.1% (n=21), respectively. The difference between the two groups was statistically significant (p=0.024). In addition, the use of medications for hypertension (p<0.001) and coronary artery disease (p=0.009) was also higher in the PES group. CONCLUSION: The higher prevalence of antidepressant drug use in patients with PES may be related to the processes of vascular damage and inflammation common to the pathogenesis of both PES and depression, as well as the high rate of chronic systemic comorbidities in these patients.
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spelling pubmed-64164842019-03-19 Pseudoexfoliation Syndrome and Antidepressant Drug Use Yaşar, Erdoğan Yıldırım, Nilgün Atalay, Eray Turk J Ophthalmol Original Article OBJECTIVES: To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications. MATERIALS AND METHODS: This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institute database (www.turksat.gov.tr/) as part of an epidemiologic study which specifically aimed to detect the prevalence of PES in the province of Eskişehir. During the examination, a detailed questionnaire was administered to determine physician-diagnosed systemic disease and drug use. RESULTS: Eight of the 2,017 participants in the study were excluded for various reasons (2 with posterior synechiae, 2 with corneal opacity, 1 uncooperative patient, 1 eviscerated patient, 1 with active adenoviral keratoconjunctivitis, and 1 with a history of angle closure). PES was detected in 100 (5%) of the 2,009 patients whose data were analyzed. The percentage of subjects with concurrent antidepressant drug use in the PES and non-PES non-glaucoma groups were 4.1% (n=3) and 1.1% (n=21), respectively. The difference between the two groups was statistically significant (p=0.024). In addition, the use of medications for hypertension (p<0.001) and coronary artery disease (p=0.009) was also higher in the PES group. CONCLUSION: The higher prevalence of antidepressant drug use in patients with PES may be related to the processes of vascular damage and inflammation common to the pathogenesis of both PES and depression, as well as the high rate of chronic systemic comorbidities in these patients. Galenos Publishing 2019-02 2019-02-28 /pmc/articles/PMC6416484/ /pubmed/30829017 http://dx.doi.org/10.4274/tjo.galenos.2018.06887 Text en © Copyright 2019 by Turkish Ophthalmological Association | Turkish Journal of Ophthalmology, published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yaşar, Erdoğan
Yıldırım, Nilgün
Atalay, Eray
Pseudoexfoliation Syndrome and Antidepressant Drug Use
title Pseudoexfoliation Syndrome and Antidepressant Drug Use
title_full Pseudoexfoliation Syndrome and Antidepressant Drug Use
title_fullStr Pseudoexfoliation Syndrome and Antidepressant Drug Use
title_full_unstemmed Pseudoexfoliation Syndrome and Antidepressant Drug Use
title_short Pseudoexfoliation Syndrome and Antidepressant Drug Use
title_sort pseudoexfoliation syndrome and antidepressant drug use
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416484/
https://www.ncbi.nlm.nih.gov/pubmed/30829017
http://dx.doi.org/10.4274/tjo.galenos.2018.06887
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