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Numerical Model for Determining the Magnetic Loss of Magnetic Fluids

Magnetic fluid hyperthermia (MFH) is a medical treatment where the temperature in the tissue is increased locally by means of heated magnetic fluid in an alternating magnetic field. In recent years, it has been the subject of a lot of research in the field of Materials, as well as in the field of cl...

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Autores principales: Beković, Miloš, Trbušić, Mislav, Gyergyek, Sašo, Trlep, Mladen, Jesenik, Marko, Szabo, Peter S. B., Hamler, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416579/
https://www.ncbi.nlm.nih.gov/pubmed/30781473
http://dx.doi.org/10.3390/ma12040591
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author Beković, Miloš
Trbušić, Mislav
Gyergyek, Sašo
Trlep, Mladen
Jesenik, Marko
Szabo, Peter S. B.
Hamler, Anton
author_facet Beković, Miloš
Trbušić, Mislav
Gyergyek, Sašo
Trlep, Mladen
Jesenik, Marko
Szabo, Peter S. B.
Hamler, Anton
author_sort Beković, Miloš
collection PubMed
description Magnetic fluid hyperthermia (MFH) is a medical treatment where the temperature in the tissue is increased locally by means of heated magnetic fluid in an alternating magnetic field. In recent years, it has been the subject of a lot of research in the field of Materials, as well as in the field of clinical testing on mice and rats. Magnetic fluid manufacturers aim to achieve three objectives; high heating capacity, biocompatibility and self-regulatory temperature effect. High heating power presents the conversion of magnetic field energy into temperature increase where it is challenging to achieve the desired therapeutic effects in terms of elevated temperature with the smallest possible amount of used material. In order to carry out the therapy, it is primarily necessary to create a fluid and perform calorimetric measurement for determining the Specific Absorption Rate (SAR) or heating power for given parameters of the magnetic field. The article presents a model based on a linear response theory for the calculation of magnetic losses and, consequently, the SAR parameters are based on the physical parameters of the liquid. The calculation model is also validated by calorimetric measurements for various amplitudes, frequencies and shapes of the magnetic field. Such a model can serve to help magnetic fluid developers in the development phase for an approximate assessment of the heating power.
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spelling pubmed-64165792019-03-29 Numerical Model for Determining the Magnetic Loss of Magnetic Fluids Beković, Miloš Trbušić, Mislav Gyergyek, Sašo Trlep, Mladen Jesenik, Marko Szabo, Peter S. B. Hamler, Anton Materials (Basel) Article Magnetic fluid hyperthermia (MFH) is a medical treatment where the temperature in the tissue is increased locally by means of heated magnetic fluid in an alternating magnetic field. In recent years, it has been the subject of a lot of research in the field of Materials, as well as in the field of clinical testing on mice and rats. Magnetic fluid manufacturers aim to achieve three objectives; high heating capacity, biocompatibility and self-regulatory temperature effect. High heating power presents the conversion of magnetic field energy into temperature increase where it is challenging to achieve the desired therapeutic effects in terms of elevated temperature with the smallest possible amount of used material. In order to carry out the therapy, it is primarily necessary to create a fluid and perform calorimetric measurement for determining the Specific Absorption Rate (SAR) or heating power for given parameters of the magnetic field. The article presents a model based on a linear response theory for the calculation of magnetic losses and, consequently, the SAR parameters are based on the physical parameters of the liquid. The calculation model is also validated by calorimetric measurements for various amplitudes, frequencies and shapes of the magnetic field. Such a model can serve to help magnetic fluid developers in the development phase for an approximate assessment of the heating power. MDPI 2019-02-16 /pmc/articles/PMC6416579/ /pubmed/30781473 http://dx.doi.org/10.3390/ma12040591 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beković, Miloš
Trbušić, Mislav
Gyergyek, Sašo
Trlep, Mladen
Jesenik, Marko
Szabo, Peter S. B.
Hamler, Anton
Numerical Model for Determining the Magnetic Loss of Magnetic Fluids
title Numerical Model for Determining the Magnetic Loss of Magnetic Fluids
title_full Numerical Model for Determining the Magnetic Loss of Magnetic Fluids
title_fullStr Numerical Model for Determining the Magnetic Loss of Magnetic Fluids
title_full_unstemmed Numerical Model for Determining the Magnetic Loss of Magnetic Fluids
title_short Numerical Model for Determining the Magnetic Loss of Magnetic Fluids
title_sort numerical model for determining the magnetic loss of magnetic fluids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416579/
https://www.ncbi.nlm.nih.gov/pubmed/30781473
http://dx.doi.org/10.3390/ma12040591
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