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Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia

INTRODUCTION: In recent years, an association between HPV-16 and oropharyngeal cancers has been reported. Therefore, it is necessary to evaluate whether vaccination decreases the exposure of HPV-16 in the oral cavity. OBJECTIVE: To evaluate the effect of vaccination on oral HPV-16 infection in high...

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Autores principales: Castillo, Andres, Osorio, Julio Cesar, Fernández, Adrián, Méndez, Fabián, Alarcón, Liliana, Arturo, Gabriela, Herrero, Rolando, Bravo, Luis Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416654/
https://www.ncbi.nlm.nih.gov/pubmed/30851448
http://dx.doi.org/10.1016/j.pvr.2019.03.001
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author Castillo, Andres
Osorio, Julio Cesar
Fernández, Adrián
Méndez, Fabián
Alarcón, Liliana
Arturo, Gabriela
Herrero, Rolando
Bravo, Luis Eduardo
author_facet Castillo, Andres
Osorio, Julio Cesar
Fernández, Adrián
Méndez, Fabián
Alarcón, Liliana
Arturo, Gabriela
Herrero, Rolando
Bravo, Luis Eduardo
author_sort Castillo, Andres
collection PubMed
description INTRODUCTION: In recent years, an association between HPV-16 and oropharyngeal cancers has been reported. Therefore, it is necessary to evaluate whether vaccination decreases the exposure of HPV-16 in the oral cavity. OBJECTIVE: To evaluate the effect of vaccination on oral HPV-16 infection in high school students in the city of Cali, Colombia. METHODS: In this cross-sectional study, HPV-16 DNA was detected in samples from the oral cavity and throat of 1,784 high school students of both genders, aged 14–17 years old, in 21 schools in the city of Cali, Colombia. The number in vaccinated girls were 944 vs., 95 unvaccinated girls and 745 unvaccinated boys. RESULTS: The HPV exposure percentages were: 0.7% in vaccinated girls, 3.2% in unvaccinated girls and 2.3% in unvaccinated boys. The odds ratio (OR) of detection of HPV-16 in vaccinated versus unvaccinated students was 0.28 (95% CI: 0.07–0.88), representing a 72% reduction in HPV-16 detection in students immunized with two doses. The odds of detection of HPV-16 in unvaccinated male students were 3.6 times those of vaccinated girls (OR = 3.6, 95% CI: 1.21–12.81) and increased to almost eight-fold in boys who had initiated sexual activity (OR = 7.74, 95% CI: 1.53–75.09). CONCLUSIONS: HPV vaccination was associated with the reduction of HPV-16 exposure percentages in the oral and oropharyngeal cavity.
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spelling pubmed-64166542019-03-25 Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia Castillo, Andres Osorio, Julio Cesar Fernández, Adrián Méndez, Fabián Alarcón, Liliana Arturo, Gabriela Herrero, Rolando Bravo, Luis Eduardo Papillomavirus Res Article INTRODUCTION: In recent years, an association between HPV-16 and oropharyngeal cancers has been reported. Therefore, it is necessary to evaluate whether vaccination decreases the exposure of HPV-16 in the oral cavity. OBJECTIVE: To evaluate the effect of vaccination on oral HPV-16 infection in high school students in the city of Cali, Colombia. METHODS: In this cross-sectional study, HPV-16 DNA was detected in samples from the oral cavity and throat of 1,784 high school students of both genders, aged 14–17 years old, in 21 schools in the city of Cali, Colombia. The number in vaccinated girls were 944 vs., 95 unvaccinated girls and 745 unvaccinated boys. RESULTS: The HPV exposure percentages were: 0.7% in vaccinated girls, 3.2% in unvaccinated girls and 2.3% in unvaccinated boys. The odds ratio (OR) of detection of HPV-16 in vaccinated versus unvaccinated students was 0.28 (95% CI: 0.07–0.88), representing a 72% reduction in HPV-16 detection in students immunized with two doses. The odds of detection of HPV-16 in unvaccinated male students were 3.6 times those of vaccinated girls (OR = 3.6, 95% CI: 1.21–12.81) and increased to almost eight-fold in boys who had initiated sexual activity (OR = 7.74, 95% CI: 1.53–75.09). CONCLUSIONS: HPV vaccination was associated with the reduction of HPV-16 exposure percentages in the oral and oropharyngeal cavity. Elsevier 2019-03-07 /pmc/articles/PMC6416654/ /pubmed/30851448 http://dx.doi.org/10.1016/j.pvr.2019.03.001 Text en © 2019 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Castillo, Andres
Osorio, Julio Cesar
Fernández, Adrián
Méndez, Fabián
Alarcón, Liliana
Arturo, Gabriela
Herrero, Rolando
Bravo, Luis Eduardo
Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia
title Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia
title_full Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia
title_fullStr Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia
title_full_unstemmed Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia
title_short Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia
title_sort effect of vaccination against oral hpv-16 infection in high school students in the city of cali, colombia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416654/
https://www.ncbi.nlm.nih.gov/pubmed/30851448
http://dx.doi.org/10.1016/j.pvr.2019.03.001
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