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The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes
BACKGROUND: Insecticide-treated bed nets (ITNs) help to control malaria by mechanically impeding the biting of mosquitoes, by repelling and irritating them and by killing them. In contrast to spatial repellency, irritancy implies that mosquitoes contact the ITN and are exposed to at least a sub-leth...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416862/ https://www.ncbi.nlm.nih.gov/pubmed/30871559 http://dx.doi.org/10.1186/s12936-019-2718-x |
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author | Thiévent, Kevin Hauser, Gaël Elaian, Obada Koella, Jacob C. |
author_facet | Thiévent, Kevin Hauser, Gaël Elaian, Obada Koella, Jacob C. |
author_sort | Thiévent, Kevin |
collection | PubMed |
description | BACKGROUND: Insecticide-treated bed nets (ITNs) help to control malaria by mechanically impeding the biting of mosquitoes, by repelling and irritating them and by killing them. In contrast to spatial repellency, irritancy implies that mosquitoes contact the ITN and are exposed to at least a sub-lethal dose of insecticide, which impedes their further blood-seeking. This would weaken the transmission of malaria, if mosquitoes are infectious. METHODS: It was therefore tested whether sub-lethal exposure to permethrin impedes blood-feeding differently in uninfected mosquitoes and in mosquitoes carrying the non-transmissible stage (oocysts) or the infectious stage (sporozoites) of the malaria parasite Plasmodium berghei. In addition, as the degree of irritancy determines the dose of insecticide the mosquitoes may receive, the irritancy to permethrin of infected and uninfected mosquitoes was compared. RESULTS: In this laboratory setting, sub-lethal exposure to permethrin inhibited the blood-seeking behaviour of Anopheles gambiae mosquitoes for almost 48 h. Although infection by malaria did not affect the irritancy of the mosquitoes to permethrin at either the developmental stage or the infectious stage, both stages of infection shortened the duration of inhibition of blood-seeking. CONCLUSIONS: The results suggest that the impact of ITNs may be weaker for malaria-infected than for uninfected mosquitoes. This will help to understand the global impact of ITNs on the transmission of malaria and gives a more complete picture of the effectiveness of that vector control measure. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12936-019-2718-x) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6416862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64168622019-03-25 The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes Thiévent, Kevin Hauser, Gaël Elaian, Obada Koella, Jacob C. Malar J Research BACKGROUND: Insecticide-treated bed nets (ITNs) help to control malaria by mechanically impeding the biting of mosquitoes, by repelling and irritating them and by killing them. In contrast to spatial repellency, irritancy implies that mosquitoes contact the ITN and are exposed to at least a sub-lethal dose of insecticide, which impedes their further blood-seeking. This would weaken the transmission of malaria, if mosquitoes are infectious. METHODS: It was therefore tested whether sub-lethal exposure to permethrin impedes blood-feeding differently in uninfected mosquitoes and in mosquitoes carrying the non-transmissible stage (oocysts) or the infectious stage (sporozoites) of the malaria parasite Plasmodium berghei. In addition, as the degree of irritancy determines the dose of insecticide the mosquitoes may receive, the irritancy to permethrin of infected and uninfected mosquitoes was compared. RESULTS: In this laboratory setting, sub-lethal exposure to permethrin inhibited the blood-seeking behaviour of Anopheles gambiae mosquitoes for almost 48 h. Although infection by malaria did not affect the irritancy of the mosquitoes to permethrin at either the developmental stage or the infectious stage, both stages of infection shortened the duration of inhibition of blood-seeking. CONCLUSIONS: The results suggest that the impact of ITNs may be weaker for malaria-infected than for uninfected mosquitoes. This will help to understand the global impact of ITNs on the transmission of malaria and gives a more complete picture of the effectiveness of that vector control measure. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12936-019-2718-x) contains supplementary material, which is available to authorized users. BioMed Central 2019-03-14 /pmc/articles/PMC6416862/ /pubmed/30871559 http://dx.doi.org/10.1186/s12936-019-2718-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Thiévent, Kevin Hauser, Gaël Elaian, Obada Koella, Jacob C. The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes |
title | The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes |
title_full | The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes |
title_fullStr | The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes |
title_full_unstemmed | The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes |
title_short | The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes |
title_sort | interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416862/ https://www.ncbi.nlm.nih.gov/pubmed/30871559 http://dx.doi.org/10.1186/s12936-019-2718-x |
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