Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment

BACKGROUND: Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant functional assays aimed at studying these failures and the efficacy of cancer immunotherapy in human are scarce. 3D tumor cultures, called tumor organoids or spheroids, represent interesting models to study...

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Detalles Bibliográficos
Autores principales: Courau, Tristan, Bonnereau, Julie, Chicoteau, Justine, Bottois, Hugo, Remark, Romain, Assante Miranda, Laura, Toubert, Antoine, Blery, Mathieu, Aparicio, Thomas, Allez, Matthieu, Le Bourhis, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417026/
https://www.ncbi.nlm.nih.gov/pubmed/30871626
http://dx.doi.org/10.1186/s40425-019-0553-9

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