Cargando…
Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
BACKGROUND: There are no known objective biomarkers to assist with the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A small number of studies have shown that ME/CFS patients exhibit an earlier onset of ventilatory threshold (VT) on the second of two cardiopulmonary exerc...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417168/ https://www.ncbi.nlm.nih.gov/pubmed/30871578 http://dx.doi.org/10.1186/s12967-019-1836-0 |
_version_ | 1783403511799611392 |
---|---|
author | Nelson, Maximillian J. Buckley, Jonathan D. Thomson, Rebecca L. Clark, Daniel Kwiatek, Richard Davison, Kade |
author_facet | Nelson, Maximillian J. Buckley, Jonathan D. Thomson, Rebecca L. Clark, Daniel Kwiatek, Richard Davison, Kade |
author_sort | Nelson, Maximillian J. |
collection | PubMed |
description | BACKGROUND: There are no known objective biomarkers to assist with the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A small number of studies have shown that ME/CFS patients exhibit an earlier onset of ventilatory threshold (VT) on the second of two cardiopulmonary exercise tests (CPET) performed on consecutive days. However, cut-off values which could be used to differentiate between ME/CFS patients have not been established. METHODS: 16 ME/CFS patients and 10 healthy controls underwent CPET on a cycle-ergometer on 2-consecutive days. Heart rate (HR), ventilation, ratings of perceived exertion (RPE) and work rate (WR) were assessed on both days. RESULTS: WR at VT decreased from day 1 to day 2 and by a greater magnitude in ME/CFS patients (p < 0.01 group × time interaction). No interaction effects were found for any other parameters. ROC curve analysis of the percentage change in WR at VT revealed decreases of − 6.3% to − 9.8% provided optimal sensitivity and specificity respectively for distinguishing between patients with ME/CFS and controls. CONCLUSION: The decrease in WR at VT of 6.3–9.8% on the 2nd day of consecutive-day CPET may represent an objective biomarker that can be used to assist with the diagnosis of ME/CFS. |
format | Online Article Text |
id | pubmed-6417168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64171682019-03-25 Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Nelson, Maximillian J. Buckley, Jonathan D. Thomson, Rebecca L. Clark, Daniel Kwiatek, Richard Davison, Kade J Transl Med Research BACKGROUND: There are no known objective biomarkers to assist with the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A small number of studies have shown that ME/CFS patients exhibit an earlier onset of ventilatory threshold (VT) on the second of two cardiopulmonary exercise tests (CPET) performed on consecutive days. However, cut-off values which could be used to differentiate between ME/CFS patients have not been established. METHODS: 16 ME/CFS patients and 10 healthy controls underwent CPET on a cycle-ergometer on 2-consecutive days. Heart rate (HR), ventilation, ratings of perceived exertion (RPE) and work rate (WR) were assessed on both days. RESULTS: WR at VT decreased from day 1 to day 2 and by a greater magnitude in ME/CFS patients (p < 0.01 group × time interaction). No interaction effects were found for any other parameters. ROC curve analysis of the percentage change in WR at VT revealed decreases of − 6.3% to − 9.8% provided optimal sensitivity and specificity respectively for distinguishing between patients with ME/CFS and controls. CONCLUSION: The decrease in WR at VT of 6.3–9.8% on the 2nd day of consecutive-day CPET may represent an objective biomarker that can be used to assist with the diagnosis of ME/CFS. BioMed Central 2019-03-14 /pmc/articles/PMC6417168/ /pubmed/30871578 http://dx.doi.org/10.1186/s12967-019-1836-0 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Nelson, Maximillian J. Buckley, Jonathan D. Thomson, Rebecca L. Clark, Daniel Kwiatek, Richard Davison, Kade Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
title | Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
title_full | Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
title_fullStr | Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
title_full_unstemmed | Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
title_short | Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
title_sort | diagnostic sensitivity of 2-day cardiopulmonary exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417168/ https://www.ncbi.nlm.nih.gov/pubmed/30871578 http://dx.doi.org/10.1186/s12967-019-1836-0 |
work_keys_str_mv | AT nelsonmaximillianj diagnosticsensitivityof2daycardiopulmonaryexercisetestinginmyalgicencephalomyelitischronicfatiguesyndrome AT buckleyjonathand diagnosticsensitivityof2daycardiopulmonaryexercisetestinginmyalgicencephalomyelitischronicfatiguesyndrome AT thomsonrebeccal diagnosticsensitivityof2daycardiopulmonaryexercisetestinginmyalgicencephalomyelitischronicfatiguesyndrome AT clarkdaniel diagnosticsensitivityof2daycardiopulmonaryexercisetestinginmyalgicencephalomyelitischronicfatiguesyndrome AT kwiatekrichard diagnosticsensitivityof2daycardiopulmonaryexercisetestinginmyalgicencephalomyelitischronicfatiguesyndrome AT davisonkade diagnosticsensitivityof2daycardiopulmonaryexercisetestinginmyalgicencephalomyelitischronicfatiguesyndrome |