Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine

Nowadays, traditional Chinese medicines (TCMs) have been reported to provide reliable therapies for viral pneumonia, but the therapeutic mechanism remains unknown. As a systemic approach, metabolomics provides an opportunity to clarify the action mechanism of TCMs, TCM syndromes or after TCM treatme...

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Autores principales: Lin, Lili, Yan, Hua, Chen, Jiabin, Xie, Huihui, Peng, Linxiu, Xie, Tong, Zhao, Xia, Wang, Shouchuan, Shan, Jinjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417174/
https://www.ncbi.nlm.nih.gov/pubmed/30911327
http://dx.doi.org/10.1186/s13020-019-0229-x
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author Lin, Lili
Yan, Hua
Chen, Jiabin
Xie, Huihui
Peng, Linxiu
Xie, Tong
Zhao, Xia
Wang, Shouchuan
Shan, Jinjun
author_facet Lin, Lili
Yan, Hua
Chen, Jiabin
Xie, Huihui
Peng, Linxiu
Xie, Tong
Zhao, Xia
Wang, Shouchuan
Shan, Jinjun
author_sort Lin, Lili
collection PubMed
description Nowadays, traditional Chinese medicines (TCMs) have been reported to provide reliable therapies for viral pneumonia, but the therapeutic mechanism remains unknown. As a systemic approach, metabolomics provides an opportunity to clarify the action mechanism of TCMs, TCM syndromes or after TCM treatment. This review aims to provide the metabolomics evidence available on TCM-based therapeutic measures against viral pneumonia. Metabolomics has been gradually applied to the efficacy evaluation of TCMs in treatment of viral pneumonia and the metabolomics analysis exhibits a systemic metabolic shift in lipid, amino acids, and energy metabolism. Currently, most studies of TCM in treatment of viral pneumonia are untargeted metabolomics and further validations on targeted metabolomics should be carried out together with molecular biology technologies.
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spelling pubmed-64171742019-03-25 Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine Lin, Lili Yan, Hua Chen, Jiabin Xie, Huihui Peng, Linxiu Xie, Tong Zhao, Xia Wang, Shouchuan Shan, Jinjun Chin Med Review Nowadays, traditional Chinese medicines (TCMs) have been reported to provide reliable therapies for viral pneumonia, but the therapeutic mechanism remains unknown. As a systemic approach, metabolomics provides an opportunity to clarify the action mechanism of TCMs, TCM syndromes or after TCM treatment. This review aims to provide the metabolomics evidence available on TCM-based therapeutic measures against viral pneumonia. Metabolomics has been gradually applied to the efficacy evaluation of TCMs in treatment of viral pneumonia and the metabolomics analysis exhibits a systemic metabolic shift in lipid, amino acids, and energy metabolism. Currently, most studies of TCM in treatment of viral pneumonia are untargeted metabolomics and further validations on targeted metabolomics should be carried out together with molecular biology technologies. BioMed Central 2019-03-12 /pmc/articles/PMC6417174/ /pubmed/30911327 http://dx.doi.org/10.1186/s13020-019-0229-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Lin, Lili
Yan, Hua
Chen, Jiabin
Xie, Huihui
Peng, Linxiu
Xie, Tong
Zhao, Xia
Wang, Shouchuan
Shan, Jinjun
Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine
title Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine
title_full Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine
title_fullStr Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine
title_full_unstemmed Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine
title_short Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine
title_sort application of metabolomics in viral pneumonia treatment with traditional chinese medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417174/
https://www.ncbi.nlm.nih.gov/pubmed/30911327
http://dx.doi.org/10.1186/s13020-019-0229-x
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