Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis

BACKGROUND: Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has often been described as an oncoprotein that preferentially contributes to the Warbu...

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Detalles Bibliográficos
Autores principales: Zhang, Mingming, Pan, Yida, Tang, Dehua, Dorfman, Robert Gregory, Xu, Lei, Zhou, Qian, Zhou, Lixing, Wang, Yuming, Li, Yang, Yin, Yuyao, Kong, Bo, Friess, Helmut, Zhao, Shimin, Wu, Jian-lin, Wang, Lei, Zou, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417221/
https://www.ncbi.nlm.nih.gov/pubmed/30866966
http://dx.doi.org/10.1186/s12964-019-0332-8

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