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Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

BACKGROUND: Metastasis is the main cause of lung cancer mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and contribute to cancer progression. Intratumoral hypoxia affects both cancer and stromal cells. Exosomes are recognized as mediators...

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Detalles Bibliográficos
Autores principales:	Zhang, Xina, Sai, Buqing, Wang, Fan, Wang, Lujuan, Wang, Yuhui, Zheng, Leliang, Li, Guiyuan, Tang, Jingqun, Xiang, Juanjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417285/ https://www.ncbi.nlm.nih.gov/pubmed/30866952 http://dx.doi.org/10.1186/s12943-019-0959-5

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