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Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format

Monoclonal antibody (mAb) immunotherapy has transformed the treatment of allergy, autoimmunity, and cancer. The interaction of mAb with Fc gamma receptors (FcγR) is often critical for efficacy. The genes encoding the low-affinity FcγR have single nucleotide polymorphisms (SNPs) and copy number varia...

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Detalles Bibliográficos
Autores principales:	Hussain, Khiyam, Hargreaves, Chantal E., Rowley, Tania F., Sopp, Joshua M., Latham, Kate V., Bhatta, Pallavi, Sherington, John, Cutler, Rona M., Humphreys, David P., Glennie, Martin J., Strefford, Jonathan C., Cragg, Mark S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417454/ https://www.ncbi.nlm.nih.gov/pubmed/30899264 http://dx.doi.org/10.3389/fimmu.2019.00390

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