Cargando…

Relationship between adiposity parameters and cognition: the “fat and jolly” hypothesis in middle-aged and elderly people in China

The association between adiposity parameters and cognition is complex. The purpose of this study was to assess the relationship between adiposity parameters and cognition in middle-aged and elderly people in China. Data were obtained from a cross-sectional study. Cognitive function was evaluated in...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Lin, Li, Jin-Long, Zhang, Li-Li, Guo, Lei-Lei, Li, Hong, Yan, Wenzhu, Li, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417533/
https://www.ncbi.nlm.nih.gov/pubmed/30855469
http://dx.doi.org/10.1097/MD.0000000000014747
_version_ 1783403583256920064
author Zhang, Lin
Li, Jin-Long
Zhang, Li-Li
Guo, Lei-Lei
Li, Hong
Yan, Wenzhu
Li, Dan
author_facet Zhang, Lin
Li, Jin-Long
Zhang, Li-Li
Guo, Lei-Lei
Li, Hong
Yan, Wenzhu
Li, Dan
author_sort Zhang, Lin
collection PubMed
description The association between adiposity parameters and cognition is complex. The purpose of this study was to assess the relationship between adiposity parameters and cognition in middle-aged and elderly people in China. Data were obtained from a cross-sectional study. Cognitive function was evaluated in 5 domains, and adiposity parameters were measured. The association between adiposity parameters and cognition was analyzed using multiple linear and binary logistic regression analyses. After controlling for confounders, men with overweight and obesity had better scores in TICS-10 ([1] total, overweight vs normal: P = .006, β = 0.04; obesity vs normal: P = .005, β = 0.04. [2] stratification by age, with age ≥ 59 years, overweight vs normal: P = .006, β = 0.05; obesity vs normal: P = .014, β = 0.05. [3] stratification by educational levels, with less than elementary education, overweight vs normal: P = .011, β = 0.05; obesity vs normal: P = .005, β = 0.05), immediate word recall ([1] total, overweight vs normal: P = .015, β = 0.04. [2] stratification by age, with age 45–58 years, overweight vs normal: P = .036, β = 0.05. [3] stratification by educational levels, with less than elementary education, overweight vs normal: P = .044, β = 0.04; above high school, overweight vs normal: P = .041, β = 0.09), self-rated memory ([1] stratification by age, with age ≥ 59 years, overweight vs normal: P = .022, β = 0.05. [2] stratification by educational levels, with less than elementary education, overweight vs normal: P = .023, β = 0.04), and drawing a picture ([1] total, overweight vs normal: OR = 1.269, 95% CI = 1.05–1.53. [2] stratification by educational levels, with less than elementary education, overweight vs normal: OR = 1.312, 95% CI = 1.06–1.63); obesity vs normal: OR = 1.601, 95% CI = 1.11–2.31 than the normal weight; women with overweight and obesity had better measure scores in the TICS-10 ([1] total, overweight vs normal: P < .0001, β = 0.06; obesity vs normal: P < .0001, β = 0.05. [2] stratification by age, with age 45–58 years, obesity vs normal: P = .007, β = 0.05; with age ≥ 59 years: overweight vs normal: P < .0001, β = 0.07, obesity vs normal: P = .002, β = 0.06. [3] stratification by educational levels, with illiterate, overweight vs normal: P = .001, β = 0.08; obesity vs normal: P = .004, β = 0.06; with less than elementary education, overweight vs normal: P < .0001, β = 0.07; obesity vs normal: P = .010, β = 0.05), immediate word recall ([1] total, overweight vs normal: P = .011, β = 0.04; obesity vs normal: P = .002, β = 0.04. [2] stratification by age, with age 45–58 years, obesity vs normal: P = .021, β = 0.05; with age ≥ 59 years: overweight vs normal: P = .003, β = 0.06. [3] stratification by educational levels, with illiterate, obesity vs normal: P = .028, β = 0.05; with less than elementary education, obesity vs normal: P = .016, β = 0.05), delay word recall ([1] total, overweight vs normal: P = .015, β = 0.03; obesity vs normal: P = .031, β = 0.03. [2] stratification by age, with age ≥ 59 years: overweight vs normal: P = .004, β = 0.06. [3] stratification by educational levels, with less than elementary education, obesity vs normal: P = .043, β = 0.04), self-rated memory ([1] total, obesity vs normal: P = .026, β = 0.03. [2] stratification by age, with age ≥ 59 years, overweight vs normal: P = .044, β = 0.04; obesity vs normal: P = .018, β = 0.05), and drawing a picture ([1] total, overweight vs normal: OR = 1.226, 95% CI = 1.06–1.42. [2] stratification by age, with age 45–58 years: overweight vs normal: OR = 1.246, 95% CI = 1.02–1.53) than the normal weight. Regarding the association between WC and cognitive function, the obesity demonstrated better mental capacity ([1] total, men: P < .0001, β = 0.06; women: P < .0001, β = 0.05. [2] stratification by age, men with age 45–58 years: P < .0001, β = 0.08; men with ≥ 59 years: P = .006, β = 0.05. women with age 45–58 years: P = .001, β = 0.06; women with ≥ 59 years: P = .012, β = 0.04. [3] stratification by educational levels, men with illiterate: P = .045, β = 0.09; men with less than elementary education: P < .0001, β = 0.08; women with illiterate: P < .0001, β = 0.09), ability to recall immediately ([1] total, men: P = .030, β = 0.03; women: P = .001, β = 0.05. [2] stratification by age, women with age 45–58 years: P = .028, β = 0.04; women with ≥ 59 years: P = .007, β = 0.05. [3] stratification by educational levels, men with less than elementary education: P = .007, β = 0.05; women with illiterate: P = .027, β = 0.05; women with less than elementary education: P = .002, β = 0.06), delay word recall ([1] total, women: P = .044, β = 0.03. [2] stratification by educational levels, men with less than elementary education: P = .023, β = 0.04), self-rated memory (stratification by educational levels, women with less than elementary education: P = .030, β = 0.04), and draw a picture ([1] total, men: OR = 1.399, 95% CI = 1.17–1.67; women: OR = 1.273, 95% CI = 1.12–1.45. [2] stratification by age, men with age 45–58 years: OR = 1.527, 95% CI = 1.15–2.03; men with age ≥ 59 years: OR = 1.284, 95% CI = 1.02–1.61; women with age 45–58 years: OR = 1.320, 95% CI = 1.10–1.58; women with age ≥ 59 years: OR = 1.223, 95% CI = 1.01–1.49. [3] stratification by educational levels, men with less than elementary education: OR = 1.528, 95% CI = 1.25–1.87; women with illiterate: OR = 1.404, 95% CI = 1.14–1.73) than the participants with normal weight after the multivariate adjustment. Our study demonstrated a significant relationship between adiposity parameters and cognition that supports the “jolly fat” hypothesis.
format Online
Article
Text
id pubmed-6417533
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-64175332019-03-16 Relationship between adiposity parameters and cognition: the “fat and jolly” hypothesis in middle-aged and elderly people in China Zhang, Lin Li, Jin-Long Zhang, Li-Li Guo, Lei-Lei Li, Hong Yan, Wenzhu Li, Dan Medicine (Baltimore) Research Article The association between adiposity parameters and cognition is complex. The purpose of this study was to assess the relationship between adiposity parameters and cognition in middle-aged and elderly people in China. Data were obtained from a cross-sectional study. Cognitive function was evaluated in 5 domains, and adiposity parameters were measured. The association between adiposity parameters and cognition was analyzed using multiple linear and binary logistic regression analyses. After controlling for confounders, men with overweight and obesity had better scores in TICS-10 ([1] total, overweight vs normal: P = .006, β = 0.04; obesity vs normal: P = .005, β = 0.04. [2] stratification by age, with age ≥ 59 years, overweight vs normal: P = .006, β = 0.05; obesity vs normal: P = .014, β = 0.05. [3] stratification by educational levels, with less than elementary education, overweight vs normal: P = .011, β = 0.05; obesity vs normal: P = .005, β = 0.05), immediate word recall ([1] total, overweight vs normal: P = .015, β = 0.04. [2] stratification by age, with age 45–58 years, overweight vs normal: P = .036, β = 0.05. [3] stratification by educational levels, with less than elementary education, overweight vs normal: P = .044, β = 0.04; above high school, overweight vs normal: P = .041, β = 0.09), self-rated memory ([1] stratification by age, with age ≥ 59 years, overweight vs normal: P = .022, β = 0.05. [2] stratification by educational levels, with less than elementary education, overweight vs normal: P = .023, β = 0.04), and drawing a picture ([1] total, overweight vs normal: OR = 1.269, 95% CI = 1.05–1.53. [2] stratification by educational levels, with less than elementary education, overweight vs normal: OR = 1.312, 95% CI = 1.06–1.63); obesity vs normal: OR = 1.601, 95% CI = 1.11–2.31 than the normal weight; women with overweight and obesity had better measure scores in the TICS-10 ([1] total, overweight vs normal: P < .0001, β = 0.06; obesity vs normal: P < .0001, β = 0.05. [2] stratification by age, with age 45–58 years, obesity vs normal: P = .007, β = 0.05; with age ≥ 59 years: overweight vs normal: P < .0001, β = 0.07, obesity vs normal: P = .002, β = 0.06. [3] stratification by educational levels, with illiterate, overweight vs normal: P = .001, β = 0.08; obesity vs normal: P = .004, β = 0.06; with less than elementary education, overweight vs normal: P < .0001, β = 0.07; obesity vs normal: P = .010, β = 0.05), immediate word recall ([1] total, overweight vs normal: P = .011, β = 0.04; obesity vs normal: P = .002, β = 0.04. [2] stratification by age, with age 45–58 years, obesity vs normal: P = .021, β = 0.05; with age ≥ 59 years: overweight vs normal: P = .003, β = 0.06. [3] stratification by educational levels, with illiterate, obesity vs normal: P = .028, β = 0.05; with less than elementary education, obesity vs normal: P = .016, β = 0.05), delay word recall ([1] total, overweight vs normal: P = .015, β = 0.03; obesity vs normal: P = .031, β = 0.03. [2] stratification by age, with age ≥ 59 years: overweight vs normal: P = .004, β = 0.06. [3] stratification by educational levels, with less than elementary education, obesity vs normal: P = .043, β = 0.04), self-rated memory ([1] total, obesity vs normal: P = .026, β = 0.03. [2] stratification by age, with age ≥ 59 years, overweight vs normal: P = .044, β = 0.04; obesity vs normal: P = .018, β = 0.05), and drawing a picture ([1] total, overweight vs normal: OR = 1.226, 95% CI = 1.06–1.42. [2] stratification by age, with age 45–58 years: overweight vs normal: OR = 1.246, 95% CI = 1.02–1.53) than the normal weight. Regarding the association between WC and cognitive function, the obesity demonstrated better mental capacity ([1] total, men: P < .0001, β = 0.06; women: P < .0001, β = 0.05. [2] stratification by age, men with age 45–58 years: P < .0001, β = 0.08; men with ≥ 59 years: P = .006, β = 0.05. women with age 45–58 years: P = .001, β = 0.06; women with ≥ 59 years: P = .012, β = 0.04. [3] stratification by educational levels, men with illiterate: P = .045, β = 0.09; men with less than elementary education: P < .0001, β = 0.08; women with illiterate: P < .0001, β = 0.09), ability to recall immediately ([1] total, men: P = .030, β = 0.03; women: P = .001, β = 0.05. [2] stratification by age, women with age 45–58 years: P = .028, β = 0.04; women with ≥ 59 years: P = .007, β = 0.05. [3] stratification by educational levels, men with less than elementary education: P = .007, β = 0.05; women with illiterate: P = .027, β = 0.05; women with less than elementary education: P = .002, β = 0.06), delay word recall ([1] total, women: P = .044, β = 0.03. [2] stratification by educational levels, men with less than elementary education: P = .023, β = 0.04), self-rated memory (stratification by educational levels, women with less than elementary education: P = .030, β = 0.04), and draw a picture ([1] total, men: OR = 1.399, 95% CI = 1.17–1.67; women: OR = 1.273, 95% CI = 1.12–1.45. [2] stratification by age, men with age 45–58 years: OR = 1.527, 95% CI = 1.15–2.03; men with age ≥ 59 years: OR = 1.284, 95% CI = 1.02–1.61; women with age 45–58 years: OR = 1.320, 95% CI = 1.10–1.58; women with age ≥ 59 years: OR = 1.223, 95% CI = 1.01–1.49. [3] stratification by educational levels, men with less than elementary education: OR = 1.528, 95% CI = 1.25–1.87; women with illiterate: OR = 1.404, 95% CI = 1.14–1.73) than the participants with normal weight after the multivariate adjustment. Our study demonstrated a significant relationship between adiposity parameters and cognition that supports the “jolly fat” hypothesis. Wolters Kluwer Health 2019-03-08 /pmc/articles/PMC6417533/ /pubmed/30855469 http://dx.doi.org/10.1097/MD.0000000000014747 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Zhang, Lin
Li, Jin-Long
Zhang, Li-Li
Guo, Lei-Lei
Li, Hong
Yan, Wenzhu
Li, Dan
Relationship between adiposity parameters and cognition: the “fat and jolly” hypothesis in middle-aged and elderly people in China
title Relationship between adiposity parameters and cognition: the “fat and jolly” hypothesis in middle-aged and elderly people in China
title_full Relationship between adiposity parameters and cognition: the “fat and jolly” hypothesis in middle-aged and elderly people in China
title_fullStr Relationship between adiposity parameters and cognition: the “fat and jolly” hypothesis in middle-aged and elderly people in China
title_full_unstemmed Relationship between adiposity parameters and cognition: the “fat and jolly” hypothesis in middle-aged and elderly people in China
title_short Relationship between adiposity parameters and cognition: the “fat and jolly” hypothesis in middle-aged and elderly people in China
title_sort relationship between adiposity parameters and cognition: the “fat and jolly” hypothesis in middle-aged and elderly people in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417533/
https://www.ncbi.nlm.nih.gov/pubmed/30855469
http://dx.doi.org/10.1097/MD.0000000000014747
work_keys_str_mv AT zhanglin relationshipbetweenadiposityparametersandcognitionthefatandjollyhypothesisinmiddleagedandelderlypeopleinchina
AT lijinlong relationshipbetweenadiposityparametersandcognitionthefatandjollyhypothesisinmiddleagedandelderlypeopleinchina
AT zhanglili relationshipbetweenadiposityparametersandcognitionthefatandjollyhypothesisinmiddleagedandelderlypeopleinchina
AT guoleilei relationshipbetweenadiposityparametersandcognitionthefatandjollyhypothesisinmiddleagedandelderlypeopleinchina
AT lihong relationshipbetweenadiposityparametersandcognitionthefatandjollyhypothesisinmiddleagedandelderlypeopleinchina
AT yanwenzhu relationshipbetweenadiposityparametersandcognitionthefatandjollyhypothesisinmiddleagedandelderlypeopleinchina
AT lidan relationshipbetweenadiposityparametersandcognitionthefatandjollyhypothesisinmiddleagedandelderlypeopleinchina