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PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis

BACKGROUND: The prognostic significance of PBK/TOPK overexpression in solid tumors remains controversial. Therefore, we carried out a meta-analysis to evaluate the impact of PBK/TOPK overexpression in solid tumors on patients’ overall survival (OS) and disease-free survival (DFS). METHODS: Relevant...

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Autores principales: Xu, Ming, Xu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417550/
https://www.ncbi.nlm.nih.gov/pubmed/30855480
http://dx.doi.org/10.1097/MD.0000000000014766
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author Xu, Ming
Xu, Song
author_facet Xu, Ming
Xu, Song
author_sort Xu, Ming
collection PubMed
description BACKGROUND: The prognostic significance of PBK/TOPK overexpression in solid tumors remains controversial. Therefore, we carried out a meta-analysis to evaluate the impact of PBK/TOPK overexpression in solid tumors on patients’ overall survival (OS) and disease-free survival (DFS). METHODS: Relevant articles were identified through searching the PubMed, Embase and Web of Science up to May 2017. The pooled hazard ratio (HR) with 95% confidence interval (CI) was used to estimate the effects. RESULTS: In this meta-analysis, 12 studies involving 1571 participants were included, PBK/TOPK overexpression was significantly associated with poor OS (pooled HR = 1.91, 95%CI = 1.22-3.00, P = .005) and short DFS (pooled HR = 1.95, 95%CI = 1.46-2.58, P < .001). CONCLUSIONS: PBK/TOPK overexpression was associated with poor survival in human solid tumors which may be a valuable prognosis biomarker and a potential therapeutic target of solid tumors.
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spelling pubmed-64175502019-03-16 PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis Xu, Ming Xu, Song Medicine (Baltimore) Research Article BACKGROUND: The prognostic significance of PBK/TOPK overexpression in solid tumors remains controversial. Therefore, we carried out a meta-analysis to evaluate the impact of PBK/TOPK overexpression in solid tumors on patients’ overall survival (OS) and disease-free survival (DFS). METHODS: Relevant articles were identified through searching the PubMed, Embase and Web of Science up to May 2017. The pooled hazard ratio (HR) with 95% confidence interval (CI) was used to estimate the effects. RESULTS: In this meta-analysis, 12 studies involving 1571 participants were included, PBK/TOPK overexpression was significantly associated with poor OS (pooled HR = 1.91, 95%CI = 1.22-3.00, P = .005) and short DFS (pooled HR = 1.95, 95%CI = 1.46-2.58, P < .001). CONCLUSIONS: PBK/TOPK overexpression was associated with poor survival in human solid tumors which may be a valuable prognosis biomarker and a potential therapeutic target of solid tumors. Wolters Kluwer Health 2019-03-08 /pmc/articles/PMC6417550/ /pubmed/30855480 http://dx.doi.org/10.1097/MD.0000000000014766 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Xu, Ming
Xu, Song
PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis
title PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis
title_full PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis
title_fullStr PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis
title_full_unstemmed PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis
title_short PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis
title_sort pbk/topk overexpression and survival in solid tumors: a prisma-compliant meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417550/
https://www.ncbi.nlm.nih.gov/pubmed/30855480
http://dx.doi.org/10.1097/MD.0000000000014766
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