Hydroxychloroquine reverses the prothrombotic state in a mouse model of antiphospholipid syndrome: Role of reduced inflammation and endothelial dysfunction

Antiphospholipid antibodies (aPL) promote endothelial dysfunction, inflammation and procoagulant state. We investigated the effect of hydroxychloroquine (HCQ) on prothrombotic state and endothelial function in mice and in human aortic endothelial cells (HAEC). Human aPL were injected to C57BL/6 mice...

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Detalles Bibliográficos
Autores principales: Miranda, Sébastien, Billoir, Paul, Damian, Louise, Thiebaut, Pierre Alain, Schapman, Damien, Le Besnerais, Maelle, Jouen, Fabienne, Galas, Ludovic, Levesque, Hervé, Le Cam-Duchez, Véronique, Joannides, Robinson, Richard, Vincent, Benhamou, Ygal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417644/
https://www.ncbi.nlm.nih.gov/pubmed/30870459
http://dx.doi.org/10.1371/journal.pone.0212614

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