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Model to improve specificity for identification of clinically-relevant expanded T cells in peripheral blood

Current methods to quantify T-cell clonal expansion only account for variance due to random sampling from a highly diverse repertoire space. We propose a beta-binomial model to incorporate time-dependent variance into the assessment of differentially abundant T-cell clones, identified by unique T Ce...

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Detalles Bibliográficos
Autores principales:	Rytlewski, Julie, Deng, Shibing, Xie, Tao, Davis, Craig, Robins, Harlan, Yusko, Erik, Bienkowska, Jadwiga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417670/ https://www.ncbi.nlm.nih.gov/pubmed/30870493 http://dx.doi.org/10.1371/journal.pone.0213684

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