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Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats

A fixed dose combination of lesinurad and allopurinol has been recently approved by USFDA and EMA for treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels with allopurinol alone. In this study, an ultra-performance hydrophilic interaction liquid...

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Detalles Bibliográficos
Autores principales:	Iqbal, Muzaffar, Ezzeldin, Essam, Herqash, Rashed Naji, Alam, Ozair
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417734/ https://www.ncbi.nlm.nih.gov/pubmed/30870504 http://dx.doi.org/10.1371/journal.pone.0213786

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