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Mean platelet volume is more important than age for defining reference intervals of platelet counts

BACKGROUND: Platelet count is known to be associated with sex, age and mean platelet volume (MPV). Sex and age were proposed for adjustment of platelet count reference intervals, but MPV is currently not used for further adjustment. We investigated the association of MPV, age and sex with platelet c...

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Autores principales: Ittermann, Till, Feig, Martin A., Petersmann, Astrid, Radke, Dörte, Greinacher, Andreas, Völzke, Henry, Thiele, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417788/
https://www.ncbi.nlm.nih.gov/pubmed/30870494
http://dx.doi.org/10.1371/journal.pone.0213658
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author Ittermann, Till
Feig, Martin A.
Petersmann, Astrid
Radke, Dörte
Greinacher, Andreas
Völzke, Henry
Thiele, Thomas
author_facet Ittermann, Till
Feig, Martin A.
Petersmann, Astrid
Radke, Dörte
Greinacher, Andreas
Völzke, Henry
Thiele, Thomas
author_sort Ittermann, Till
collection PubMed
description BACKGROUND: Platelet count is known to be associated with sex, age and mean platelet volume (MPV). Sex and age were proposed for adjustment of platelet count reference intervals, but MPV is currently not used for further adjustment. We investigated the association of MPV, age and sex with platelet counts and established individualized reference ranges respecting MPV. METHODS: The association of platelet count with age, sex and MPV was assessed in healthy participants (n = 3,033 individuals; 1,542 women) in the cross-sectional population-based cohort Study of Health in Pomerania. Reference intervals respecting age, sex, and MPV were estimated using quantile regressions for the 2.5(th) and 97.5(th) percentile. RESULTS: Women had higher platelet counts than men (239 vs. 207 x10(9)/L, p<0.001). Platelet counts correlated with age (p<0.001) and MPV (p<0.001). Quantile regression of lower and upper platelet count limits correlated less with age in female (p = 0.047 for 2.5(th) percentile; p = 0.906 for 97.5(th) percentile) and male subjects (p = 0.029 for 2.5(th) percentile; p = 0.195 for 97.5(th) percentile) compared to MPV (p<0.001 for upper and lower limit for both sexes). After adjustment for MPV, age did no longer correlate with the 2.5(th) (p = 0.165) or 97.5(th) percentile (p = 0.999) of platelet count. In contrast, after adjustment for age, MPV levels still significantly correlated with 2.5(th), 50(th) and 97.5(th) percentile (p<0.001). CONCLUSION: MPV and sex have a stronger association with platelet count than age. MPV should be considered to adjust platelet count reference intervals and needs to be respected as confounder for platelet counts in epidemiological studies and clinical practice.
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spelling pubmed-64177882019-04-01 Mean platelet volume is more important than age for defining reference intervals of platelet counts Ittermann, Till Feig, Martin A. Petersmann, Astrid Radke, Dörte Greinacher, Andreas Völzke, Henry Thiele, Thomas PLoS One Research Article BACKGROUND: Platelet count is known to be associated with sex, age and mean platelet volume (MPV). Sex and age were proposed for adjustment of platelet count reference intervals, but MPV is currently not used for further adjustment. We investigated the association of MPV, age and sex with platelet counts and established individualized reference ranges respecting MPV. METHODS: The association of platelet count with age, sex and MPV was assessed in healthy participants (n = 3,033 individuals; 1,542 women) in the cross-sectional population-based cohort Study of Health in Pomerania. Reference intervals respecting age, sex, and MPV were estimated using quantile regressions for the 2.5(th) and 97.5(th) percentile. RESULTS: Women had higher platelet counts than men (239 vs. 207 x10(9)/L, p<0.001). Platelet counts correlated with age (p<0.001) and MPV (p<0.001). Quantile regression of lower and upper platelet count limits correlated less with age in female (p = 0.047 for 2.5(th) percentile; p = 0.906 for 97.5(th) percentile) and male subjects (p = 0.029 for 2.5(th) percentile; p = 0.195 for 97.5(th) percentile) compared to MPV (p<0.001 for upper and lower limit for both sexes). After adjustment for MPV, age did no longer correlate with the 2.5(th) (p = 0.165) or 97.5(th) percentile (p = 0.999) of platelet count. In contrast, after adjustment for age, MPV levels still significantly correlated with 2.5(th), 50(th) and 97.5(th) percentile (p<0.001). CONCLUSION: MPV and sex have a stronger association with platelet count than age. MPV should be considered to adjust platelet count reference intervals and needs to be respected as confounder for platelet counts in epidemiological studies and clinical practice. Public Library of Science 2019-03-14 /pmc/articles/PMC6417788/ /pubmed/30870494 http://dx.doi.org/10.1371/journal.pone.0213658 Text en © 2019 Ittermann et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ittermann, Till
Feig, Martin A.
Petersmann, Astrid
Radke, Dörte
Greinacher, Andreas
Völzke, Henry
Thiele, Thomas
Mean platelet volume is more important than age for defining reference intervals of platelet counts
title Mean platelet volume is more important than age for defining reference intervals of platelet counts
title_full Mean platelet volume is more important than age for defining reference intervals of platelet counts
title_fullStr Mean platelet volume is more important than age for defining reference intervals of platelet counts
title_full_unstemmed Mean platelet volume is more important than age for defining reference intervals of platelet counts
title_short Mean platelet volume is more important than age for defining reference intervals of platelet counts
title_sort mean platelet volume is more important than age for defining reference intervals of platelet counts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417788/
https://www.ncbi.nlm.nih.gov/pubmed/30870494
http://dx.doi.org/10.1371/journal.pone.0213658
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