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Oral Cavity Squamous Cell Carcinoma Xenografts Retain Complex Genotypes and Intertumor Molecular Heterogeneity

Herein, we report an oral cavity squamous cell carcinoma (OCSCC) patient-derived xenograft (PDX) platform, with genomic annotation useful for co-clinical trial and mechanistic studies. Genomic analysis included whole-exome sequencing (WES) and transcriptome sequencing (RNA-seq) on 16 tumors and matc...

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Detalles Bibliográficos
Autores principales:	Campbell, Katie M., Lin, Tianxiang, Zolkind, Paul, Barnell, Erica K., Skidmore, Zachary L., Winkler, Ashley E., Law, Jonathan H., Mardis, Elaine R., Wartman, Lukas D., Adkins, Douglas R., Chernock, Rebecca D., Griffith, Malachi, Uppaluri, Ravindra, Griffith, Obi L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417872/ https://www.ncbi.nlm.nih.gov/pubmed/30134176 http://dx.doi.org/10.1016/j.celrep.2018.07.058

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