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The incidence of Cushing’s disease: a nationwide Swedish study

BACKGROUND: Studies on the incidence of Cushing’s disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden. METHODS: Patients registered with a diagnostic code for Cu...

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Autores principales: Ragnarsson, Oskar, Olsson, Daniel S., Chantzichristos, Dimitrios, Papakokkinou, Eleni, Dahlqvist, Per, Segerstedt, Elin, Olsson, Tommy, Petersson, Maria, Berinder, Katarina, Bensing, Sophie, Höybye, Charlotte, Edén Engström, Britt, Burman, Pia, Bonelli, Lorenza, Follin, Cecilia, Petranek, David, Erfurth, Eva Marie, Wahlberg, Jeanette, Ekman, Bertil, Åkerman, Anna-Karin, Schwarcz, Erik, Bryngelsson, Ing-Liss, Johannsson, Gudmundur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418061/
https://www.ncbi.nlm.nih.gov/pubmed/30799512
http://dx.doi.org/10.1007/s11102-019-00951-1
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author Ragnarsson, Oskar
Olsson, Daniel S.
Chantzichristos, Dimitrios
Papakokkinou, Eleni
Dahlqvist, Per
Segerstedt, Elin
Olsson, Tommy
Petersson, Maria
Berinder, Katarina
Bensing, Sophie
Höybye, Charlotte
Edén Engström, Britt
Burman, Pia
Bonelli, Lorenza
Follin, Cecilia
Petranek, David
Erfurth, Eva Marie
Wahlberg, Jeanette
Ekman, Bertil
Åkerman, Anna-Karin
Schwarcz, Erik
Bryngelsson, Ing-Liss
Johannsson, Gudmundur
author_facet Ragnarsson, Oskar
Olsson, Daniel S.
Chantzichristos, Dimitrios
Papakokkinou, Eleni
Dahlqvist, Per
Segerstedt, Elin
Olsson, Tommy
Petersson, Maria
Berinder, Katarina
Bensing, Sophie
Höybye, Charlotte
Edén Engström, Britt
Burman, Pia
Bonelli, Lorenza
Follin, Cecilia
Petranek, David
Erfurth, Eva Marie
Wahlberg, Jeanette
Ekman, Bertil
Åkerman, Anna-Karin
Schwarcz, Erik
Bryngelsson, Ing-Liss
Johannsson, Gudmundur
author_sort Ragnarsson, Oskar
collection PubMed
description BACKGROUND: Studies on the incidence of Cushing’s disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden. METHODS: Patients registered with a diagnostic code for Cushing’s syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient Registry. The CD diagnosis was validated by reviewing clinical, biochemical, imaging, and histopathological data. RESULTS: Of 1317 patients identified, 534 (41%) had confirmed CD. One-hundred-and-fifty-six (12%) patients had other forms of CS, 41 (3%) had probable but unconfirmed CD, and 334 (25%) had diagnoses unrelated to CS. The mean (95% confidence interval) annual incidence between 1987 and 2013 of confirmed CD was 1.6 (1.4–1.8) cases per million. 1987–1995, 1996–2004, and 2005–2013, the mean annual incidence was 1.5 (1.1–1.8), 1.4 (1.0–1.7) and 2.0 (1.7–2.3) cases per million, respectively. During the last time period the incidence was higher than during the first and second time periods (P < 0.05). CONCLUSION: The incidence of CD in Sweden (1.6 cases per million) is in agreement with most previous reports. A higher incidence between 2005 and 2013 compared to 1987–2004 was noticed. Whether this reflects a truly increased incidence of the disease, or simply an increased awareness, earlier recognition, and earlier diagnosis can, however, not be answered. This study also illustrates the importance of validation of the diagnosis of CD in epidemiological research. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11102-019-00951-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-64180612019-04-03 The incidence of Cushing’s disease: a nationwide Swedish study Ragnarsson, Oskar Olsson, Daniel S. Chantzichristos, Dimitrios Papakokkinou, Eleni Dahlqvist, Per Segerstedt, Elin Olsson, Tommy Petersson, Maria Berinder, Katarina Bensing, Sophie Höybye, Charlotte Edén Engström, Britt Burman, Pia Bonelli, Lorenza Follin, Cecilia Petranek, David Erfurth, Eva Marie Wahlberg, Jeanette Ekman, Bertil Åkerman, Anna-Karin Schwarcz, Erik Bryngelsson, Ing-Liss Johannsson, Gudmundur Pituitary Article BACKGROUND: Studies on the incidence of Cushing’s disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden. METHODS: Patients registered with a diagnostic code for Cushing’s syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient Registry. The CD diagnosis was validated by reviewing clinical, biochemical, imaging, and histopathological data. RESULTS: Of 1317 patients identified, 534 (41%) had confirmed CD. One-hundred-and-fifty-six (12%) patients had other forms of CS, 41 (3%) had probable but unconfirmed CD, and 334 (25%) had diagnoses unrelated to CS. The mean (95% confidence interval) annual incidence between 1987 and 2013 of confirmed CD was 1.6 (1.4–1.8) cases per million. 1987–1995, 1996–2004, and 2005–2013, the mean annual incidence was 1.5 (1.1–1.8), 1.4 (1.0–1.7) and 2.0 (1.7–2.3) cases per million, respectively. During the last time period the incidence was higher than during the first and second time periods (P < 0.05). CONCLUSION: The incidence of CD in Sweden (1.6 cases per million) is in agreement with most previous reports. A higher incidence between 2005 and 2013 compared to 1987–2004 was noticed. Whether this reflects a truly increased incidence of the disease, or simply an increased awareness, earlier recognition, and earlier diagnosis can, however, not be answered. This study also illustrates the importance of validation of the diagnosis of CD in epidemiological research. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11102-019-00951-1) contains supplementary material, which is available to authorized users. Springer US 2019-02-25 2019 /pmc/articles/PMC6418061/ /pubmed/30799512 http://dx.doi.org/10.1007/s11102-019-00951-1 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Ragnarsson, Oskar
Olsson, Daniel S.
Chantzichristos, Dimitrios
Papakokkinou, Eleni
Dahlqvist, Per
Segerstedt, Elin
Olsson, Tommy
Petersson, Maria
Berinder, Katarina
Bensing, Sophie
Höybye, Charlotte
Edén Engström, Britt
Burman, Pia
Bonelli, Lorenza
Follin, Cecilia
Petranek, David
Erfurth, Eva Marie
Wahlberg, Jeanette
Ekman, Bertil
Åkerman, Anna-Karin
Schwarcz, Erik
Bryngelsson, Ing-Liss
Johannsson, Gudmundur
The incidence of Cushing’s disease: a nationwide Swedish study
title The incidence of Cushing’s disease: a nationwide Swedish study
title_full The incidence of Cushing’s disease: a nationwide Swedish study
title_fullStr The incidence of Cushing’s disease: a nationwide Swedish study
title_full_unstemmed The incidence of Cushing’s disease: a nationwide Swedish study
title_short The incidence of Cushing’s disease: a nationwide Swedish study
title_sort incidence of cushing’s disease: a nationwide swedish study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418061/
https://www.ncbi.nlm.nih.gov/pubmed/30799512
http://dx.doi.org/10.1007/s11102-019-00951-1
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