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Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation

The therapeutic effects of simvastatin for renal cell carcinoma (RCC) are controversial. In this study, the effects of simvastatin on the carcinogenic properties of 3-methylcholanthrene (3MC; an aryl-hydrocarbon receptor [AhR] agonist) in human renal epithelial cells (hRECs) were investigated. We ex...

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Detalles Bibliográficos
Autores principales:	Chang, Chih-Cheng, Huang, Kuo-How, Hsu, Sung-Po, Lee, Yuan-Chii G., Sue, Yuh-Mou, Juan, Shu-Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418087/ https://www.ncbi.nlm.nih.gov/pubmed/30872677 http://dx.doi.org/10.1038/s41598-019-40757-6

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