Cargando…

Carotid artery plaque intervention with Tongxinluo capsule (CAPITAL): A multicenter randomized double-blind parallel-group placebo-controlled study

To determine whether the traditional Chinese medicine Tongxinluo (TXL) is efficacious at retarding the progression of carotid atherosclerotic lesions, a total of 1,212 patients with a focal intima-media thickness (IMT) of ≥1.2 mm of the carotid arteries received TXL or placebo capsules in addition t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Mei, Liu, Yan, Xu, Mingjun, Zhang, Lei, Liu, Xiaoling, Zhao, Yuxia, Zhu, Fang, Xu, Rui, Ou, Zhihong, Wang, Ying, Liu, Qigong, Ma, Shuping, Wang, Tian, He, Maolin, Lu, Qinghua, Li, Honghua, Huang, Jihan, Zhang, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418108/ https://www.ncbi.nlm.nih.gov/pubmed/30872737 http://dx.doi.org/10.1038/s41598-019-41118-z

Ejemplares similares

Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora
por: Qi, Yan, et al.
Publicado: (2022)

Systematic Review of Tongxinluo Capsule on the Therapeutic Effect and Hemorheology of Patients with Transient Ischemic Attack
por: Yang, Peng, et al.
Publicado: (2021)

Tongxinluo mitigates atherogenesis by regulating angiogenic factors and inhibiting vasa vasorum neovascularization in apolipoprotein E-deficient mice
por: Ma, Lianyue, et al.
Publicado: (2016)

Tongxinluo capsule in combination with conventional therapies for stable angina pectoris: A meta-analysis and systematic review
por: Feng, Ruli, et al.
Publicado: (2023)

Chinese Patent Medicine Tongxinluo Capsule for Hypertension: A Systematic Review of Randomised Controlled Trials
por: Wang, Jie, et al.
Publicado: (2014)

Tongxinluo Capsule Combined with Atorvastatin for Coronary Heart Disease: A Systematic Review and Meta-Analysis
por: Liu, Qiao, et al.
Publicado: (2021)

Experimental evidence and network pharmacology-based analysis reveal the molecular mechanism of Tongxinluo capsule administered in coronary heart diseases
por: Li, Guode, et al.
Publicado: (2020)

Inhibiting leukocyte‐endothelial cell interactions by Chinese medicine Tongxinluo capsule alleviates no‐reflow after arterial recanalization in ischemic stroke
por: Liu, Shen, et al.
Publicado: (2023)

A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Study of the Effects of Tongxinluo Capsules in Acute Coronary Syndrome Patients with High On-Treatment Platelet Reactivity
por: Zhang, Lei, et al.
Publicado: (2018)

Effects of tongxinluo on the neointima formation and expression of inflammatory cytokines in rats after carotid artery balloon injury
por: Yao, En-Hui, et al.
Publicado: (2014)

Tongxinluo Reverses the Hypoxia-suppressed Claudin-9 in Cardiac Microvascular Endothelial Cells
por: Liu, Kun, et al.
Publicado: (2016)

Truth of Floating Carotid Plaques
por: Liu, Wei, et al.
Publicado: (2017)

To Investigate the Clinical Efficacy and Potential Mechanism of Tongxinluo Capsules in Preventing Coronary Restenosis Based on Meta-Analysis and Network Pharmacology Analysis
por: Wei, Wen-Xin, et al.
Publicado: (2023)

Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability
por: Xu, Xiangli, et al.
Publicado: (2021)

PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats
por: Cui, Xiaopei, et al.
Publicado: (2016)

Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease
por: Zhang, Huiping, et al.
Publicado: (2015)

Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease
por: Gu, Jiao-Jiao, et al.
Publicado: (2023)

Efficacy and Safety of Tongxinluo Capsule as Adjunctive Treatment for Unstable Angina Pectoris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
por: Li, Pengqi, et al.
Publicado: (2021)

Potential Effectiveness of Chinese Patent Medicine Tongxinluo Capsule for Secondary Prevention After Acute Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
por: Li, Min, et al.
Publicado: (2018)

Early identification of carotid vulnerable plaque in asymptomatic patients
por: Jiao, Yungen, et al.
Publicado: (2020)

Traditional Chinese Medicine Tongxinluo Improves Cardiac Function of Rats with Dilated Cardiomyopathy
por: Shen, Fang-Fang, et al.
Publicado: (2014)

Traditional Chinese Medication Tongxinluo Attenuates Lipidosis in Ox-LDL-Stimulated Macrophages by Enhancing Beclin-1-Induced Autophagy
por: Chen, Yifei, et al.
Publicado: (2021)

Effect of Tongxinluo on Nephrin Expression via Inhibition of Notch1/Snail Pathway in Diabetic Rats
por: Cui, Fangqiang, et al.
Publicado: (2015)

Tongxinluo Improves Apolipoprotein E-Deficient Mouse Heart Function
por: Yuan, Guo-Qiang, et al.
Publicado: (2018)

Tongxinluo promotes axonal plasticity and functional recovery after stroke
por: Wang, Xiaoting, et al.
Publicado: (2020)

Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats
por: Wang, Bing, et al.
Publicado: (2021)

Prediction of Carotid In-Stent Restenosis by Computed Tomography Angiography Carotid Plaque-Based Radiomics
por: Cheng, Xiaoqing, et al.
Publicado: (2022)

Transcriptomic and Proteomic Profiling of Human Stable and Unstable Carotid Atherosclerotic Plaques
por: Bao, Mei-hua, et al.
Publicado: (2021)

A comparative study of the vibro-impact capsule systems with one-sided and two-sided constraints
por: Yan, Yao, et al.
Publicado: (2017)

Significance of high resolution MRI in the identification of carotid plaque
por: Sun, Yong, et al.
Publicado: (2020)

Autophagy in Atherosclerosis: A Phenomenon Found in Human Carotid Atherosclerotic Plaques
por: Liu, Huihui, et al.
Publicado: (2015)

Tongxinluo Prevents Endothelial Dysfunction Induced by Homocysteine Thiolactone In Vivo via Suppression of Oxidative Stress
por: Zhang, Yi, et al.
Publicado: (2015)

Efficacy and Safety of Different Courses of Tongxinluo Capsule as Adjuvant Therapy for Coronary Heart Disease after Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
por: Hui, Jiaqi, et al.
Publicado: (2022)

Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats
por: Cheng, Xiao, et al.
Publicado: (2014)

Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age
por: Liu, Zhihao, et al.
Publicado: (2020)

Tongxinluo enhances the effect of atorvastatin on the treatment of atherosclerosis with chronic obstructive pulmonary disease by maintaining the pulmonary microvascular barrier
por: Kuang, Xiangnan, et al.
Publicado: (2022)

Comparison of carotid‐femoral and brachial‐ankle pulse wave velocity in association with carotid plaque in a Chinese community‐based population
por: Liu, Bo, et al.
Publicado: (2022)

Association between lipid profiles and presence of carotid plaque
por: Liu, Yanhua, et al.
Publicado: (2019)

A Single-Cell Atlas of the Atherosclerotic Plaque in the Femoral Artery and the Heterogeneity in Macrophage Subtypes between Carotid and Femoral Atherosclerosis
por: Wang, Ping, et al.
Publicado: (2022)

Correlation between aortic/carotid atherosclerotic plaques and cerebral infarction
por: WANG, BAOJUN, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_k5ei296fn4ok9k5ulv9hlhvq3m