Cargando…

Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair

Adhesion signaling between epithelial cells and the extracellular matrix plays a critical role in maintaining tissue homeostasis and the response to tissue damage. Focal adhesion kinase (FAK) and its close relative Pyk2 are non-receptor tyrosine kinases that mediate adhesion signaling to promote cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomas, Keena S., Owen, Katherine A., Conger, Kathryn, Llewellyn, Ryan A., Bouton, Amy H., Casanova, James E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418130/ https://www.ncbi.nlm.nih.gov/pubmed/30872746 http://dx.doi.org/10.1038/s41598-019-41116-1

Ejemplares similares

FAK Regulates Intestinal Epithelial Cell Survival and Proliferation during Mucosal Wound Healing
por: Owen, Katherine A., et al.
Publicado: (2011)

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development
por: Naser, Rayan, et al.
Publicado: (2018)

FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β
por: Gao, Chenxi, et al.
Publicado: (2015)

Non-Overlapping Functions for Pyk2 and FAK in Osteoblasts during Fluid Shear Stress-Induced Mechanotransduction
por: Young, Suzanne R. L., et al.
Publicado: (2011)

Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells
por: Genna, Alessandro, et al.
Publicado: (2018)

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK
por: Weis, Sara M., et al.
Publicado: (2008)

FAK/PYK2 inhibitors defactinib and VS-4718 enhance immune checkpoint inhibitor efficacy
por: Ring, Jennifer, et al.
Publicado: (2015)

Microglial Cytokines Induce Invasiveness and Proliferation of Human Glioblastoma through Pyk2 and FAK Activation
por: Nuñez, Rebeca E., et al.
Publicado: (2021)

Targeting FAK/PYK2 with SJP1602 for Anti-Tumor Activity in Triple-Negative Breast Cancer
por: Jeon, Myeongjin, et al.
Publicado: (2023)

Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice
por: Alves, Gustavo Ferreira, et al.
Publicado: (2022)

Targeted Inhibition of FAK, PYK2 and BCL-XL Synergistically Enhances Apoptosis in Ovarian Clear Cell Carcinoma Cell Lines
por: Yoon, Heejei, et al.
Publicado: (2014)

Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction
por: Miao, Lei, et al.
Publicado: (2016)

FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation
por: Murphy, James M., et al.
Publicado: (2019)

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
por: Ryzhakov, Grigory, et al.
Publicado: (2021)

Pyk2 for perfect bones
por: LeBrasseur, Nicole
Publicado: (2007)

Author Correction: Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction
por: Miao, Lei, et al.
Publicado: (2022)

Pyk2/FAK Signaling Is Upregulated in Recurrent Glioblastoma Tumors in a C57BL/6/GL261 Glioma Implantation Model
por: Ortiz Rivera, Jescelica, et al.
Publicado: (2023)

Role of Pyk2 in Human Cancers
por: Shen, Ting, et al.
Publicado: (2018)

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
por: Lim, Yangmi, et al.
Publicado: (2008)

Impact of the Whole Genome Duplication Event on PYK Activity and Effects of a PYK1 Mutation on Metabolism in S. cerevisiae
por: Chen, Hong, et al.
Publicado: (2021)

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
por: Xu, Cheng-Shi, et al.
Publicado: (2015)

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
por: Raab, Monika, et al.
Publicado: (2017)

Activation of Focal Adhesion Kinase by Salmonella Suppresses Autophagy via an Akt/mTOR Signaling Pathway and Promotes Bacterial Survival in Macrophages
por: Owen, Katherine A., et al.
Publicado: (2014)

FAK regulates epithelial-mesenchymal transition in adenomyosis
por: Zheng, Dexuan, et al.
Publicado: (2018)

The Complexity and Redundancy of Epithelial Barrier Function
por: Steinert, Peter M.
Publicado: (2000)

Breast Cancer Antiestrogen Resistance 3 (BCAR3) Promotes Cell Motility by Regulating Actin Cytoskeletal and Adhesion Remodeling in Invasive Breast Cancer Cells
por: Wilson, Ashley L., et al.
Publicado: (2013)

Novel Role of Src in Priming Pyk2 Phosphorylation
por: Zhao, Ming, et al.
Publicado: (2016)

Convergent Effects of Resveratrol and PYK2 on Prostate Cells
por: Conte, Andrea, et al.
Publicado: (2016)

PYK2 at the Intersection of Signaling Pathways in Pancreatic Cancer
por: Means, Anna L.
Publicado: (2019)

The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases
por: de Pins, Benoit, et al.
Publicado: (2021)

Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing
por: Wang, Qinggang, et al.
Publicado: (2019)

Bovine Lactoferricin Induces Intestinal Epithelial Cell Activation through Phosphorylation of FAK and Paxillin and Prevents Rotavirus Infection
por: Jeong, Ye Young, et al.
Publicado: (2021)

Suppression of Pyk2 Kinase and Cellular Activities by Fip200
por: Ueda, Hiroki, et al.
Publicado: (2000)

Pyk2 promotes tumor progression in renal cell carcinoma
por: Zhao, Tangliang, et al.
Publicado: (2018)

Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons
por: López-Molina, Laura, et al.
Publicado: (2022)

Non-Catalytic Functions of Pyk2 and Fyn Regulate Late Stage Adhesion in Human T Cells
por: Chapman, Nicole M., et al.
Publicado: (2012)

Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion
por: Heuslein, Joshua L., et al.
Publicado: (2016)

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3
por: Lee, Jaewon J., et al.
Publicado: (2018)

Hematopoietic Pyk2 regulates migration of differentiated HL-60 cells
por: Wang, Lin, et al.
Publicado: (2010)

PYK2 promotes HER2-positive breast cancer invasion
por: Al-Juboori, Shaymaa IK., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_35fnoumnbhbvbj1gln8lblmdgg