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Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients

Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 i...

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Autores principales: Fourdinier, Ophélie, Schepers, Eva, Metzinger-Le Meuth, Valérie, Glorieux, Griet, Liabeuf, Sophie, Verbeke, Francis, Vanholder, Raymond, Brigant, Benjamin, Pletinck, Anneleen, Diouf, Momar, Burtey, Stéphane, Choukroun, Gabriel, Massy, Ziad A., Metzinger, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418179/
https://www.ncbi.nlm.nih.gov/pubmed/30872798
http://dx.doi.org/10.1038/s41598-019-41101-8
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author Fourdinier, Ophélie
Schepers, Eva
Metzinger-Le Meuth, Valérie
Glorieux, Griet
Liabeuf, Sophie
Verbeke, Francis
Vanholder, Raymond
Brigant, Benjamin
Pletinck, Anneleen
Diouf, Momar
Burtey, Stéphane
Choukroun, Gabriel
Massy, Ziad A.
Metzinger, Laurent
author_facet Fourdinier, Ophélie
Schepers, Eva
Metzinger-Le Meuth, Valérie
Glorieux, Griet
Liabeuf, Sophie
Verbeke, Francis
Vanholder, Raymond
Brigant, Benjamin
Pletinck, Anneleen
Diouf, Momar
Burtey, Stéphane
Choukroun, Gabriel
Massy, Ziad A.
Metzinger, Laurent
author_sort Fourdinier, Ophélie
collection PubMed
description Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 in a large cohort of 601 CKD patients (CKD stage G1 to G5 patients or on renal replacement therapy – CKD G5D) from Ghent University Hospital and 31 healthy controls. All-cause mortality and cardiovascular and renal events were registered as endpoints over a 6 year follow-up period. miR-126 levels were significantly lower from CKD stage G2 on, compared to controls. The serum levels of miR-223 were significantly lower from CKD stage G3B on. When considering overall mortality, patients with levels of either miR-126 or miR-223 below the median had a lower survival rate. Similar results were observed for CV and renal events. The observed link between the two miRNAs’ seric levels and mortality, cardiovascular events or renal events in CKD appears to depend on eGFR. However, this does not preclude their potential role in the pathophysiology of CKD. In conclusion, CKD is associated with a decrease in circulating miR-223 and miR-126 levels.
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spelling pubmed-64181792019-03-18 Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients Fourdinier, Ophélie Schepers, Eva Metzinger-Le Meuth, Valérie Glorieux, Griet Liabeuf, Sophie Verbeke, Francis Vanholder, Raymond Brigant, Benjamin Pletinck, Anneleen Diouf, Momar Burtey, Stéphane Choukroun, Gabriel Massy, Ziad A. Metzinger, Laurent Sci Rep Article Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 in a large cohort of 601 CKD patients (CKD stage G1 to G5 patients or on renal replacement therapy – CKD G5D) from Ghent University Hospital and 31 healthy controls. All-cause mortality and cardiovascular and renal events were registered as endpoints over a 6 year follow-up period. miR-126 levels were significantly lower from CKD stage G2 on, compared to controls. The serum levels of miR-223 were significantly lower from CKD stage G3B on. When considering overall mortality, patients with levels of either miR-126 or miR-223 below the median had a lower survival rate. Similar results were observed for CV and renal events. The observed link between the two miRNAs’ seric levels and mortality, cardiovascular events or renal events in CKD appears to depend on eGFR. However, this does not preclude their potential role in the pathophysiology of CKD. In conclusion, CKD is associated with a decrease in circulating miR-223 and miR-126 levels. Nature Publishing Group UK 2019-03-14 /pmc/articles/PMC6418179/ /pubmed/30872798 http://dx.doi.org/10.1038/s41598-019-41101-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Fourdinier, Ophélie
Schepers, Eva
Metzinger-Le Meuth, Valérie
Glorieux, Griet
Liabeuf, Sophie
Verbeke, Francis
Vanholder, Raymond
Brigant, Benjamin
Pletinck, Anneleen
Diouf, Momar
Burtey, Stéphane
Choukroun, Gabriel
Massy, Ziad A.
Metzinger, Laurent
Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients
title Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients
title_full Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients
title_fullStr Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients
title_full_unstemmed Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients
title_short Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients
title_sort serum levels of mir-126 and mir-223 and outcomes in chronic kidney disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418179/
https://www.ncbi.nlm.nih.gov/pubmed/30872798
http://dx.doi.org/10.1038/s41598-019-41101-8
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