Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications

Liquid biopsy is indispensable for the resolution of current medical issues, such as the cost of developing new drugs and predicting responses of patients to drugs. In this sense, not only the technology for liquid biopsy but also the target biomolecules for biomarkers need to be identified. Extrace...

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Autores principales: Kosaka, Nobuyoshi, Kogure, Akiko, Yamamoto, Tomofumi, Urabe, Fumihiko, Usuba, Wataru, Prieto-Vila, Marta, Ochiya, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418231/
https://www.ncbi.nlm.nih.gov/pubmed/30872565
http://dx.doi.org/10.1038/s12276-019-0219-1
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author Kosaka, Nobuyoshi
Kogure, Akiko
Yamamoto, Tomofumi
Urabe, Fumihiko
Usuba, Wataru
Prieto-Vila, Marta
Ochiya, Takahiro
author_facet Kosaka, Nobuyoshi
Kogure, Akiko
Yamamoto, Tomofumi
Urabe, Fumihiko
Usuba, Wataru
Prieto-Vila, Marta
Ochiya, Takahiro
author_sort Kosaka, Nobuyoshi
collection PubMed
description Liquid biopsy is indispensable for the resolution of current medical issues, such as the cost of developing new drugs and predicting responses of patients to drugs. In this sense, not only the technology for liquid biopsy but also the target biomolecules for biomarkers need to be identified. Extracellular vesicles (EVs), which contain various proteins, including membrane-bound proteins, and RNAs, including mRNA and long/short noncoding RNAs, have emerged as ideal targets for liquid biopsy. These complex biomolecules are covered by a lipid bilayer, which can protect them from degradation. In this review, we review current topics regarding EVs as cancer biomarkers and introduce technologies used for these recently emerged biomolecules.
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spelling pubmed-64182312019-03-22 Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications Kosaka, Nobuyoshi Kogure, Akiko Yamamoto, Tomofumi Urabe, Fumihiko Usuba, Wataru Prieto-Vila, Marta Ochiya, Takahiro Exp Mol Med Review Article Liquid biopsy is indispensable for the resolution of current medical issues, such as the cost of developing new drugs and predicting responses of patients to drugs. In this sense, not only the technology for liquid biopsy but also the target biomolecules for biomarkers need to be identified. Extracellular vesicles (EVs), which contain various proteins, including membrane-bound proteins, and RNAs, including mRNA and long/short noncoding RNAs, have emerged as ideal targets for liquid biopsy. These complex biomolecules are covered by a lipid bilayer, which can protect them from degradation. In this review, we review current topics regarding EVs as cancer biomarkers and introduce technologies used for these recently emerged biomolecules. Nature Publishing Group UK 2019-03-15 /pmc/articles/PMC6418231/ /pubmed/30872565 http://dx.doi.org/10.1038/s12276-019-0219-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Kosaka, Nobuyoshi
Kogure, Akiko
Yamamoto, Tomofumi
Urabe, Fumihiko
Usuba, Wataru
Prieto-Vila, Marta
Ochiya, Takahiro
Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
title Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
title_full Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
title_fullStr Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
title_full_unstemmed Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
title_short Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
title_sort exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418231/
https://www.ncbi.nlm.nih.gov/pubmed/30872565
http://dx.doi.org/10.1038/s12276-019-0219-1
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