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Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation

Optical tweezers are a highly versatile tool for exploration of the mesoscopic world, permitting non-contact manipulation of nanoscale objects. However, direct illumination with intense lasers restricts their use with live biological specimens, and limits the types of materials that can be trapped....

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Autores principales: Būtaitė, Unė G., Gibson, Graham M., Ho, Ying-Lung D., Taverne, Mike, Taylor, Jonathan M., Phillips, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418258/
https://www.ncbi.nlm.nih.gov/pubmed/30872572
http://dx.doi.org/10.1038/s41467-019-08968-7
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author Būtaitė, Unė G.
Gibson, Graham M.
Ho, Ying-Lung D.
Taverne, Mike
Taylor, Jonathan M.
Phillips, David B.
author_facet Būtaitė, Unė G.
Gibson, Graham M.
Ho, Ying-Lung D.
Taverne, Mike
Taylor, Jonathan M.
Phillips, David B.
author_sort Būtaitė, Unė G.
collection PubMed
description Optical tweezers are a highly versatile tool for exploration of the mesoscopic world, permitting non-contact manipulation of nanoscale objects. However, direct illumination with intense lasers restricts their use with live biological specimens, and limits the types of materials that can be trapped. Here we demonstrate an indirect optical trapping platform which circumvents these limitations by using hydrodynamic forces to exert nanoscale-precision control over aqueous particles, without directly illuminating them. Our concept is based on optically actuated micro-robotics: closed-loop control enables highly localised flow-fields to be sculpted by precisely piloting the motion of optically-trapped micro-rotors. We demonstrate 2D trapping of absorbing particles which cannot be directly optically trapped, stabilise the position and orientation of yeast cells, and demonstrate independent control over multiple objects simultaneously. Our work expands the capabilities of optical tweezers platforms, and represents a new paradigm for manipulation of aqueous mesoscopic systems.
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spelling pubmed-64182582019-03-18 Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation Būtaitė, Unė G. Gibson, Graham M. Ho, Ying-Lung D. Taverne, Mike Taylor, Jonathan M. Phillips, David B. Nat Commun Article Optical tweezers are a highly versatile tool for exploration of the mesoscopic world, permitting non-contact manipulation of nanoscale objects. However, direct illumination with intense lasers restricts their use with live biological specimens, and limits the types of materials that can be trapped. Here we demonstrate an indirect optical trapping platform which circumvents these limitations by using hydrodynamic forces to exert nanoscale-precision control over aqueous particles, without directly illuminating them. Our concept is based on optically actuated micro-robotics: closed-loop control enables highly localised flow-fields to be sculpted by precisely piloting the motion of optically-trapped micro-rotors. We demonstrate 2D trapping of absorbing particles which cannot be directly optically trapped, stabilise the position and orientation of yeast cells, and demonstrate independent control over multiple objects simultaneously. Our work expands the capabilities of optical tweezers platforms, and represents a new paradigm for manipulation of aqueous mesoscopic systems. Nature Publishing Group UK 2019-03-14 /pmc/articles/PMC6418258/ /pubmed/30872572 http://dx.doi.org/10.1038/s41467-019-08968-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Būtaitė, Unė G.
Gibson, Graham M.
Ho, Ying-Lung D.
Taverne, Mike
Taylor, Jonathan M.
Phillips, David B.
Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation
title Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation
title_full Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation
title_fullStr Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation
title_full_unstemmed Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation
title_short Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation
title_sort indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418258/
https://www.ncbi.nlm.nih.gov/pubmed/30872572
http://dx.doi.org/10.1038/s41467-019-08968-7
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