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Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers

BACKGROUND: Lead (Pb) is broadly used in various industries and causes irreversible damage to human tissues, organs, and systems. Studies have revealed that lead exerts toxic effects via interfering with calcium channel. METHODS: In the present study, we investigated whether single nucleotide polymo...

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Autores principales: Liu, Jiting, Zhang, Li, Feng, Lixia, Xu, Ming, Gao, Yue, Zhou, Peng, Yu, Zhengmin, Zhu, Baoli, An, Yan, Zhang, Hengdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418352/
https://www.ncbi.nlm.nih.gov/pubmed/30666830
http://dx.doi.org/10.1002/mgg3.562
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author Liu, Jiting
Zhang, Li
Feng, Lixia
Xu, Ming
Gao, Yue
Zhou, Peng
Yu, Zhengmin
Zhu, Baoli
An, Yan
Zhang, Hengdong
author_facet Liu, Jiting
Zhang, Li
Feng, Lixia
Xu, Ming
Gao, Yue
Zhou, Peng
Yu, Zhengmin
Zhu, Baoli
An, Yan
Zhang, Hengdong
author_sort Liu, Jiting
collection PubMed
description BACKGROUND: Lead (Pb) is broadly used in various industries and causes irreversible damage to human tissues, organs, and systems. Studies have revealed that lead exerts toxic effects via interfering with calcium channel. METHODS: In the present study, we investigated whether single nucleotide polymorphisms (SNPs) in TRPV5, a calcium channel‐related gene, were associated with lead exposure susceptibility. By using TaqMan SNP genotyping, we performed genotyping of eight TRPV5 tag‐SNPs in 1,130 lead‐exposed Chinese workers with similar lead exposure level. RESULTS: Single nucleotide polymorphism rs4252424 was significantly associated with lead susceptibility, measured by blood lead level (BLL) (β = −0.069, p (linear) = 0.029). However, there was no significant association between any other seven SNPs and BLL. The further expression Quantitative Trait Loci displayed that CC genotype of rs4252424 is significant associated with higher BLL than CT (p < 0.0001). CONCLUSION: We conclude that SNP rs4252424 has the potential to evaluate lead susceptibility in the Chinese occupational population, and further enhance lead exposure prevention and intervention.
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spelling pubmed-64183522019-03-27 Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers Liu, Jiting Zhang, Li Feng, Lixia Xu, Ming Gao, Yue Zhou, Peng Yu, Zhengmin Zhu, Baoli An, Yan Zhang, Hengdong Mol Genet Genomic Med Original Articles BACKGROUND: Lead (Pb) is broadly used in various industries and causes irreversible damage to human tissues, organs, and systems. Studies have revealed that lead exerts toxic effects via interfering with calcium channel. METHODS: In the present study, we investigated whether single nucleotide polymorphisms (SNPs) in TRPV5, a calcium channel‐related gene, were associated with lead exposure susceptibility. By using TaqMan SNP genotyping, we performed genotyping of eight TRPV5 tag‐SNPs in 1,130 lead‐exposed Chinese workers with similar lead exposure level. RESULTS: Single nucleotide polymorphism rs4252424 was significantly associated with lead susceptibility, measured by blood lead level (BLL) (β = −0.069, p (linear) = 0.029). However, there was no significant association between any other seven SNPs and BLL. The further expression Quantitative Trait Loci displayed that CC genotype of rs4252424 is significant associated with higher BLL than CT (p < 0.0001). CONCLUSION: We conclude that SNP rs4252424 has the potential to evaluate lead susceptibility in the Chinese occupational population, and further enhance lead exposure prevention and intervention. John Wiley and Sons Inc. 2019-01-21 /pmc/articles/PMC6418352/ /pubmed/30666830 http://dx.doi.org/10.1002/mgg3.562 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Liu, Jiting
Zhang, Li
Feng, Lixia
Xu, Ming
Gao, Yue
Zhou, Peng
Yu, Zhengmin
Zhu, Baoli
An, Yan
Zhang, Hengdong
Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers
title Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers
title_full Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers
title_fullStr Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers
title_full_unstemmed Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers
title_short Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers
title_sort association between single nucleotide polymorphism (rs4252424) in trpv5 calcium channel gene and lead poisoning in chinese workers
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418352/
https://www.ncbi.nlm.nih.gov/pubmed/30666830
http://dx.doi.org/10.1002/mgg3.562
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