Cargando…

Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population

BACKGROUND: Tuberculosis (TB) is the second‐leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)‐DQB2, HLA‐DPA1, and HLA‐DPB1 may partly explain individual differences in TB susceptibility. METHODS: We performed a hospital‐based case–control study to assess the ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xue, Cao, Xudong, Zhang, Wanjiang, Zhang, Le, Lu, Lijun, Li, Xinyue, El‐Ashram, Saeed, Wu, Jiangdong, Chen, Chuangfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418356/
https://www.ncbi.nlm.nih.gov/pubmed/30600606
http://dx.doi.org/10.1002/mgg3.544
_version_ 1783403722393518080
author Wang, Xue
Cao, Xudong
Zhang, Wanjiang
Zhang, Le
Lu, Lijun
Li, Xinyue
El‐Ashram, Saeed
Wu, Jiangdong
Chen, Chuangfu
author_facet Wang, Xue
Cao, Xudong
Zhang, Wanjiang
Zhang, Le
Lu, Lijun
Li, Xinyue
El‐Ashram, Saeed
Wu, Jiangdong
Chen, Chuangfu
author_sort Wang, Xue
collection PubMed
description BACKGROUND: Tuberculosis (TB) is the second‐leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)‐DQB2, HLA‐DPA1, and HLA‐DPB1 may partly explain individual differences in TB susceptibility. METHODS: We performed a hospital‐based case–control study to assess the genetic influence of single‐nucleotide polymorphisms (SNPs) in the HLA (HLA‐DPA, HLA‐DPB, and HLA‐DQB) on the development of TB. There were 248 TB‐infected cases and 340 healthy controls in this study. RESULTS: The HLA‐DQB2 rs7453920 genotype GG was applied as the reference group, the GA genotype was related to a considerably magnified risk of TB (GA vs. GG: adjusted OR = 1.547, 95% CI = 1.039–2.304, p = 0.032). Nevertheless, the other two SNPs were not associated with TB risk. Stratified analyses suggested that tobacco was associated with an increased risk of TB in HLA‐DQB2 rs7453920 G>A. CONCLUSION: These results suggested that the functional HLA‐DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB. Nevertheless, the results were based on a limited sample size, and larger well‐designed studies are expected to confirm these preliminary findings.
format Online
Article
Text
id pubmed-6418356
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-64183562019-03-27 Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population Wang, Xue Cao, Xudong Zhang, Wanjiang Zhang, Le Lu, Lijun Li, Xinyue El‐Ashram, Saeed Wu, Jiangdong Chen, Chuangfu Mol Genet Genomic Med Original Articles BACKGROUND: Tuberculosis (TB) is the second‐leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)‐DQB2, HLA‐DPA1, and HLA‐DPB1 may partly explain individual differences in TB susceptibility. METHODS: We performed a hospital‐based case–control study to assess the genetic influence of single‐nucleotide polymorphisms (SNPs) in the HLA (HLA‐DPA, HLA‐DPB, and HLA‐DQB) on the development of TB. There were 248 TB‐infected cases and 340 healthy controls in this study. RESULTS: The HLA‐DQB2 rs7453920 genotype GG was applied as the reference group, the GA genotype was related to a considerably magnified risk of TB (GA vs. GG: adjusted OR = 1.547, 95% CI = 1.039–2.304, p = 0.032). Nevertheless, the other two SNPs were not associated with TB risk. Stratified analyses suggested that tobacco was associated with an increased risk of TB in HLA‐DQB2 rs7453920 G>A. CONCLUSION: These results suggested that the functional HLA‐DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB. Nevertheless, the results were based on a limited sample size, and larger well‐designed studies are expected to confirm these preliminary findings. John Wiley and Sons Inc. 2019-01-01 /pmc/articles/PMC6418356/ /pubmed/30600606 http://dx.doi.org/10.1002/mgg3.544 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Wang, Xue
Cao, Xudong
Zhang, Wanjiang
Zhang, Le
Lu, Lijun
Li, Xinyue
El‐Ashram, Saeed
Wu, Jiangdong
Chen, Chuangfu
Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population
title Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population
title_full Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population
title_fullStr Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population
title_full_unstemmed Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population
title_short Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population
title_sort association of human leukocyte antigens‐dqb2/dpa1/dpb1 polymorphism and pulmonary tuberculosis in the chinese uygur population
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418356/
https://www.ncbi.nlm.nih.gov/pubmed/30600606
http://dx.doi.org/10.1002/mgg3.544
work_keys_str_mv AT wangxue associationofhumanleukocyteantigensdqb2dpa1dpb1polymorphismandpulmonarytuberculosisinthechineseuygurpopulation
AT caoxudong associationofhumanleukocyteantigensdqb2dpa1dpb1polymorphismandpulmonarytuberculosisinthechineseuygurpopulation
AT zhangwanjiang associationofhumanleukocyteantigensdqb2dpa1dpb1polymorphismandpulmonarytuberculosisinthechineseuygurpopulation
AT zhangle associationofhumanleukocyteantigensdqb2dpa1dpb1polymorphismandpulmonarytuberculosisinthechineseuygurpopulation
AT lulijun associationofhumanleukocyteantigensdqb2dpa1dpb1polymorphismandpulmonarytuberculosisinthechineseuygurpopulation
AT lixinyue associationofhumanleukocyteantigensdqb2dpa1dpb1polymorphismandpulmonarytuberculosisinthechineseuygurpopulation
AT elashramsaeed associationofhumanleukocyteantigensdqb2dpa1dpb1polymorphismandpulmonarytuberculosisinthechineseuygurpopulation
AT wujiangdong associationofhumanleukocyteantigensdqb2dpa1dpb1polymorphismandpulmonarytuberculosisinthechineseuygurpopulation
AT chenchuangfu associationofhumanleukocyteantigensdqb2dpa1dpb1polymorphismandpulmonarytuberculosisinthechineseuygurpopulation