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Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population
BACKGROUND: Tuberculosis (TB) is the second‐leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)‐DQB2, HLA‐DPA1, and HLA‐DPB1 may partly explain individual differences in TB susceptibility. METHODS: We performed a hospital‐based case–control study to assess the ge...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418356/ https://www.ncbi.nlm.nih.gov/pubmed/30600606 http://dx.doi.org/10.1002/mgg3.544 |
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author | Wang, Xue Cao, Xudong Zhang, Wanjiang Zhang, Le Lu, Lijun Li, Xinyue El‐Ashram, Saeed Wu, Jiangdong Chen, Chuangfu |
author_facet | Wang, Xue Cao, Xudong Zhang, Wanjiang Zhang, Le Lu, Lijun Li, Xinyue El‐Ashram, Saeed Wu, Jiangdong Chen, Chuangfu |
author_sort | Wang, Xue |
collection | PubMed |
description | BACKGROUND: Tuberculosis (TB) is the second‐leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)‐DQB2, HLA‐DPA1, and HLA‐DPB1 may partly explain individual differences in TB susceptibility. METHODS: We performed a hospital‐based case–control study to assess the genetic influence of single‐nucleotide polymorphisms (SNPs) in the HLA (HLA‐DPA, HLA‐DPB, and HLA‐DQB) on the development of TB. There were 248 TB‐infected cases and 340 healthy controls in this study. RESULTS: The HLA‐DQB2 rs7453920 genotype GG was applied as the reference group, the GA genotype was related to a considerably magnified risk of TB (GA vs. GG: adjusted OR = 1.547, 95% CI = 1.039–2.304, p = 0.032). Nevertheless, the other two SNPs were not associated with TB risk. Stratified analyses suggested that tobacco was associated with an increased risk of TB in HLA‐DQB2 rs7453920 G>A. CONCLUSION: These results suggested that the functional HLA‐DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB. Nevertheless, the results were based on a limited sample size, and larger well‐designed studies are expected to confirm these preliminary findings. |
format | Online Article Text |
id | pubmed-6418356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64183562019-03-27 Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population Wang, Xue Cao, Xudong Zhang, Wanjiang Zhang, Le Lu, Lijun Li, Xinyue El‐Ashram, Saeed Wu, Jiangdong Chen, Chuangfu Mol Genet Genomic Med Original Articles BACKGROUND: Tuberculosis (TB) is the second‐leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)‐DQB2, HLA‐DPA1, and HLA‐DPB1 may partly explain individual differences in TB susceptibility. METHODS: We performed a hospital‐based case–control study to assess the genetic influence of single‐nucleotide polymorphisms (SNPs) in the HLA (HLA‐DPA, HLA‐DPB, and HLA‐DQB) on the development of TB. There were 248 TB‐infected cases and 340 healthy controls in this study. RESULTS: The HLA‐DQB2 rs7453920 genotype GG was applied as the reference group, the GA genotype was related to a considerably magnified risk of TB (GA vs. GG: adjusted OR = 1.547, 95% CI = 1.039–2.304, p = 0.032). Nevertheless, the other two SNPs were not associated with TB risk. Stratified analyses suggested that tobacco was associated with an increased risk of TB in HLA‐DQB2 rs7453920 G>A. CONCLUSION: These results suggested that the functional HLA‐DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB. Nevertheless, the results were based on a limited sample size, and larger well‐designed studies are expected to confirm these preliminary findings. John Wiley and Sons Inc. 2019-01-01 /pmc/articles/PMC6418356/ /pubmed/30600606 http://dx.doi.org/10.1002/mgg3.544 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Wang, Xue Cao, Xudong Zhang, Wanjiang Zhang, Le Lu, Lijun Li, Xinyue El‐Ashram, Saeed Wu, Jiangdong Chen, Chuangfu Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population |
title | Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population |
title_full | Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population |
title_fullStr | Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population |
title_full_unstemmed | Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population |
title_short | Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population |
title_sort | association of human leukocyte antigens‐dqb2/dpa1/dpb1 polymorphism and pulmonary tuberculosis in the chinese uygur population |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418356/ https://www.ncbi.nlm.nih.gov/pubmed/30600606 http://dx.doi.org/10.1002/mgg3.544 |
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