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Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation
Dysfunction of motor cortices is thought to contribute to motor disorders such as Parkinson’s disease (PD). However, little is known on the link between cortical dopaminergic loss, abnormalities in motor cortex neural activity and motor deficits. We address the role of dopamine in modulating motor c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418393/ https://www.ncbi.nlm.nih.gov/pubmed/30721984 http://dx.doi.org/10.1093/cercor/bhz005 |
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author | Chen, Ke Vincis, Roberto Fontanini, Alfredo |
author_facet | Chen, Ke Vincis, Roberto Fontanini, Alfredo |
author_sort | Chen, Ke |
collection | PubMed |
description | Dysfunction of motor cortices is thought to contribute to motor disorders such as Parkinson’s disease (PD). However, little is known on the link between cortical dopaminergic loss, abnormalities in motor cortex neural activity and motor deficits. We address the role of dopamine in modulating motor cortical activity by focusing on the anterior lateral motor cortex (ALM) of mice performing a cued-licking task. We first demonstrate licking deficits and concurrent alterations of spiking activity in ALM of head-fixed mice with unilateral depletion of dopaminergic neurons (i.e., mice injected with 6-OHDA into the medial forebrain bundle). Hemilesioned mice displayed delayed licking initiation, shorter duration of licking bouts, and lateral deviation of tongue protrusions. In parallel with these motor deficits, we observed a reduction in the prevalence of cue responsive neurons and altered preparatory activity. Acute and local blockade of D1 receptors in ALM recapitulated some of the key behavioral and neural deficits observed in hemilesioned mice. Altogether, our data show a direct relationship between cortical D1 receptor modulation, cue-evoked, and preparatory activity in ALM, and licking initiation. |
format | Online Article Text |
id | pubmed-6418393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-64183932019-03-20 Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation Chen, Ke Vincis, Roberto Fontanini, Alfredo Cereb Cortex Original Articles Dysfunction of motor cortices is thought to contribute to motor disorders such as Parkinson’s disease (PD). However, little is known on the link between cortical dopaminergic loss, abnormalities in motor cortex neural activity and motor deficits. We address the role of dopamine in modulating motor cortical activity by focusing on the anterior lateral motor cortex (ALM) of mice performing a cued-licking task. We first demonstrate licking deficits and concurrent alterations of spiking activity in ALM of head-fixed mice with unilateral depletion of dopaminergic neurons (i.e., mice injected with 6-OHDA into the medial forebrain bundle). Hemilesioned mice displayed delayed licking initiation, shorter duration of licking bouts, and lateral deviation of tongue protrusions. In parallel with these motor deficits, we observed a reduction in the prevalence of cue responsive neurons and altered preparatory activity. Acute and local blockade of D1 receptors in ALM recapitulated some of the key behavioral and neural deficits observed in hemilesioned mice. Altogether, our data show a direct relationship between cortical D1 receptor modulation, cue-evoked, and preparatory activity in ALM, and licking initiation. Oxford University Press 2019-04 2019-02-04 /pmc/articles/PMC6418393/ /pubmed/30721984 http://dx.doi.org/10.1093/cercor/bhz005 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Articles Chen, Ke Vincis, Roberto Fontanini, Alfredo Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation |
title | Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation |
title_full | Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation |
title_fullStr | Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation |
title_full_unstemmed | Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation |
title_short | Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation |
title_sort | disruption of cortical dopaminergic modulation impairs preparatory activity and delays licking initiation |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418393/ https://www.ncbi.nlm.nih.gov/pubmed/30721984 http://dx.doi.org/10.1093/cercor/bhz005 |
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