The emerging role of sorting nexins in cardiovascular diseases

The sorting nexin (SNX) family consists of a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play pivotal roles in the regulation of protein trafficking. This includes the entire endocytic pathway, such as endocytosis, endosomal sorting, and endosomal sig...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jian, Villar, Van Anthony M., Rozyyev, Selim, Jose, Pedro A., Zeng, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418407/
https://www.ncbi.nlm.nih.gov/pubmed/30877150
http://dx.doi.org/10.1042/CS20190034
_version_ 1783403732627619840
author Yang, Jian
Villar, Van Anthony M.
Rozyyev, Selim
Jose, Pedro A.
Zeng, Chunyu
author_facet Yang, Jian
Villar, Van Anthony M.
Rozyyev, Selim
Jose, Pedro A.
Zeng, Chunyu
author_sort Yang, Jian
collection PubMed
description The sorting nexin (SNX) family consists of a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play pivotal roles in the regulation of protein trafficking. This includes the entire endocytic pathway, such as endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX pathway are involved in several forms of cardiovascular disease (CVD). Moreover, SNX gene variants are associated with CVDs. In this review, we discuss the current knowledge on SNX-mediated regulatory mechanisms and their roles in the pathogenesis and treatment of CVDs.
format Online
Article
Text
id pubmed-6418407
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-64184072019-03-26 The emerging role of sorting nexins in cardiovascular diseases Yang, Jian Villar, Van Anthony M. Rozyyev, Selim Jose, Pedro A. Zeng, Chunyu Clin Sci (Lond) Review Articles The sorting nexin (SNX) family consists of a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play pivotal roles in the regulation of protein trafficking. This includes the entire endocytic pathway, such as endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX pathway are involved in several forms of cardiovascular disease (CVD). Moreover, SNX gene variants are associated with CVDs. In this review, we discuss the current knowledge on SNX-mediated regulatory mechanisms and their roles in the pathogenesis and treatment of CVDs. Portland Press Ltd. 2019-03-15 /pmc/articles/PMC6418407/ /pubmed/30877150 http://dx.doi.org/10.1042/CS20190034 Text en © 2019 The Author(s). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Articles
Yang, Jian
Villar, Van Anthony M.
Rozyyev, Selim
Jose, Pedro A.
Zeng, Chunyu
The emerging role of sorting nexins in cardiovascular diseases
title The emerging role of sorting nexins in cardiovascular diseases
title_full The emerging role of sorting nexins in cardiovascular diseases
title_fullStr The emerging role of sorting nexins in cardiovascular diseases
title_full_unstemmed The emerging role of sorting nexins in cardiovascular diseases
title_short The emerging role of sorting nexins in cardiovascular diseases
title_sort emerging role of sorting nexins in cardiovascular diseases
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418407/
https://www.ncbi.nlm.nih.gov/pubmed/30877150
http://dx.doi.org/10.1042/CS20190034
work_keys_str_mv AT yangjian theemergingroleofsortingnexinsincardiovasculardiseases
AT villarvananthonym theemergingroleofsortingnexinsincardiovasculardiseases
AT rozyyevselim theemergingroleofsortingnexinsincardiovasculardiseases
AT josepedroa theemergingroleofsortingnexinsincardiovasculardiseases
AT zengchunyu theemergingroleofsortingnexinsincardiovasculardiseases
AT yangjian emergingroleofsortingnexinsincardiovasculardiseases
AT villarvananthonym emergingroleofsortingnexinsincardiovasculardiseases
AT rozyyevselim emergingroleofsortingnexinsincardiovasculardiseases
AT josepedroa emergingroleofsortingnexinsincardiovasculardiseases
AT zengchunyu emergingroleofsortingnexinsincardiovasculardiseases

Ejemplares similares